Plasma lipids in Helicobacter pylori infected pregnant women
May 2009
Dyslipidaemia is a common feature of pregnancy and Helicobacter pylori infection respectively. We hypothesised that pregnant women infected with H. pylori may have increased disorder in lipid metabolism than non-infected pregnant women and thus estimated the plasma lipids in pregnant women with H. pylori infection. Forty (40) pregnant women (GA ≥ 11 weeks) attending ANC of the Department...
Platelets: Indicator of inflammation in COPD
May 2009
COPD is a disease presenting with pulmonary inflammation as well as a systemic one. The present study was conducted to see if platelet count may be accepted as an indicator of systemic inflammation other than erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). 964 smoker patients without any concomitant disease were divided into groups as COPD and non-COPD according to spirometric values. Physical...
Relationship between homocystein blood level and multiple sclerosis
May 2009
Multiple sclerosis which is identified by the triad of inflammation, demyelination, and gliosis, is a chronic disease beginning early in adulthood. It is a disease of time and place, meaning involves different locations in different time intervals, and results in a variability of symptoms and signs including visual complains, motor weakness, and cerebellar problems. Although the main cause of the disease is unknown,...
Could we reduce the incidence of methicillin-resistant Staphylococcus aureus (MRSA) infection in Otitis externa
May 2009
The incidence of MRSA is once again on the agenda for the hospital management. This strain of micro organism presents a challenge for ENT doctors worldwide. Despite many strict measures taken all over the world, the figures appear to be rising; there has been a steady increase in the number of cases of nosocomial MRSA infections. We examined all external ear swabs samples taken from patients...
Serum malondialdehyde, glutathione and nitric oxide levels in patients infected with Entamoeba coli
May 2009
While Entamoeba histolytica is a major human pathogen, other species like Entamoeba coliare not known to be pathogenic. Thus, there have been studies investigating the possible pathogenic nature of E. coli. The aim of this study is to evaluate the serum levels of malondialdehyde (MDA), glutathione (GSH) and nitric oxide (NO) levels in E. coli-infected patients. The study was conducted between...
A faster and safer staining technique for acid fast bacilli in resource-poor setting
May 2009
The traditional Ziehl-Neelsen (ZN) method used for the staining of acid fast bacilli contains phenol and because of the hazardous nature and inherent danger of phenol, this study was carried out to develop a faster and safer method in our environment that will exclude toxic phenol from the staining solution. “Morning fresh”, a commercial liquid dish washing solution with super grease cutting power and citrus...
Pharmacogenomics: benefits of personalized medicines
April 2009
Pharmacogenomics is a science that examines the inherited variations in genes that dictate drug response and explores the ways these variations can be used to predict whether a patient will have a good, bad, or no response at all to a drug. It refers to the general study of all of the many different genes that determine drug behavior. It could also guide companies in designing clinical trials that would more...
An unusual cause of acute tympanic membrane perforation: a case report
April 2009
This is a case report of a 26 – year old lady who presented in the Accident and Emergency Department of our hospital with complaints of sudden onset of right otalgia, tinnitus and loss of hearing which she claimed started at about 12:30 h after vigorous kissing incident. The tympanic membrane was ruptured. She was managed conservatively with oral antibiotics with spontaneous and complete healing of the perforated...
Methotrexate-induced toxic epidermal necrolysis: a case report
April 2009
Methotrexate (MTX) is a folic acid antagonist that inhibits the enzyme dihydrofolate reductase resulting in decreased cell levels of tetrahydrofolate. Adverse cutaneous reactions to MTX are usually dose-related and have been mainly reported in patients receiving extremely large doses of chemotherapy. Toxicity can affect multiple organ systems including bone marrow, liver, intestinal tract, kidneys, lungs, skin, and...
Intraoperative low molecular weight heparin and postoperative bleeding
April 2009
A case of postoperative bleeding associated with low molecular weight heparin (LMWH) administration is reported. A literature search suggests that perioperative bleeding can be as high as 11% when LMWH is administered intraoperatively. When administered 6 h postoperatively, LMWH does not signi-ficantly increase the risk of bleeding whilst retaining efficacy for venous thromboembolism prop-hylaxis. Although LMWH has not...
Efficacy of some antibacterial agents on Staphylococcus aureus isolated from various burn cases
April 2009
The present study aimed to determine the major bacterial types from various burn cases and a study of antibacterial activity of plant extracts against Staphylococcus aureus isolated from burn cases in comparison with standard antibiotics.A total of 35 specimens were collected from burned patients (both sex, various degrees of burns) in burns unit of Al-Basrah General Hospital and Alsader Teaching...
The influence of mode of delivery on the levels of high-sensitivity C - reactive protein determined in umbilical cord blood
April 2009
Data suggest that the fetus responds to chronic hypoxia by higher umbilical cord blood high-sensitive CRP concentrations. In order to evaluate the effects of acute hypoxia on fetus, cord blood high-sensitive CRP concentrations according to the delivery mode were compared. High-sensitive CRP concentration was measured by an immunonephelometric method in umbilical cord blood samples from 45 newborns born by...
Bone tumors at Addis Ababa University, Ethiopia: agreement between radiological and histopathological diagnoses, a -5-year analysis at Black-Lion Teaching Hospital
April 2009
The study aims at looking into clinical, radiological and histopathological agreement in diagnosing bone tumors and elaborates the spectrum of bone tumors referred to Black-Lion Hospital, BLH. All bone tumor patients, who presented to all the three departments at BLH between the study periods of December 2003 – March 2008 were recruited. the radiological and histopathological diagnoses made were categorized...
Aminothienoandrostane: novel promising anti-tumor agent
April 2009
The sensitivity of liver to chemotherapy provides the basis of novel investigational treatment. An amino thienoandrostane derivative was synthesized and tested in vitro for anti-tumor activity against heapto-ma cell lines (HepG2) using MTT assay. Also the in vivo anti-tumor activity was evaluated against Ehrlich ascites carcinoma (EAC). After 24 h of tumor inoculation, the tested compound was...
Insulin resistance and blood pressure in Nigerian type 2 diabetic patients
April 2009
Considerable interest has been generated on the possible role of insulin resistance (IR) in the etiology and sustenance of hypertension among type-2 diabetic subjects. There is paucity of data on this relationship on African diabetic patients. The aim of this study is to show the relationship between homeostasis model assessment (HOMA) derived insulin resistance (IR) scores and blood pressure among type-2 diabetic...
Anthropometric comparison of nasal indices between Andoni and Okrika tribes of Rivers State, Nigeria
April 2009
A comparative study on Nasal Index was carried out on subjects from Andoni and Okrika tribes of Rivers State in the Niger Delta region of Nigeria. Four hundred individuals were randomly selected from each tribe comprising 200 males and 200 females, respectively. The ages of the subjects ranged from 21-30 years. The height of the nose (NH) and the breadth of the nose (NB) were measured for each subject using a sliding...
Performance of syphilis serology in students of Ambrose Alli University, Ekpoma, Nigeria
April 2009
5 ml of venous blood was aseptically collected from 112 consenting, apparently healthy students of Ambrose Alli University Ekpoma, Nigeria. The enrollees were 62 males and 50 females (age range, 15 – 44 years). The Rapid Plasma Reagin (RPR) and Immunochromatographic tests (Spodex Diagnostic Company) were used to screen and confirm the presence of syphilitic antibodies in their serum and plasma. Out of the 112...
Editorial: Chemists at Max Planck Institute (Germany) regenerate Artemisinin from its waste product
March 2009
Prostatic adenocarcinoma coexisting with schistosomiasis: A case report and review of literature
March 2009
Adenocarcinoma of the prostate is the commonest form of cancer in men and the second leading cause of cancer death. Not much is known about the aetiology of prostatic cancer. We report a rare case of prostatic adenocarcinoma coexisting with schistosomiasis of the prostate, and review of literature. The association between schistosomiasis and cancer has been well documented in bladder cancer, implicating the...
Update to risk factors for hepatocellular carcinoma
March 2009
Hepatocellular carcinoma (HCC) became a prevalent disease in many populations worldwide. It initiates many economic problems in management modalities and leads to increasing mortality rates. Many trials are made all over the world to implement specific early markers for detection and prediction of the disease, hoping to set a more precise strategy for liver cancer prevention. Unfortunately, many economic, cultural and...
Brief review of sarcoidosis of the thyroid gland
March 2009
Sarcoidosis of the thyroid gland is rare. It is rarely reported in the medical literature. In this review article we go over various presentation of sarcoidosis of the thyroid gland, ways to diagnose it, and treatment options. Key words: Sarcoidosis, thyroid gland, hypothyroidism, Graves' disease
Differential induction of LRP16 by liganded and unliganded estrogen receptor a in SKOV3 ovarian carcinoma cells
March 2009
Previously, we investigated the induction effect of LRP16 expression by estrogen (E2) and established a feed-forward mechanism that activated ERa transactivation in estrogen-dependent epithelial cancer cells. LRP16 is required for ERa signaling transduction by functioning as an ERa coactivator. In this study, we demonstrated that LRP16 expression was up-regulated in E2-responsive BG-1 ovarian cancer...
In situ distribution of hepatitis C virus (HCV) RNA in the liver: Relationship to histopathology and serum HCV-RNA levels
March 2009
In situ hybridization (ISH) technique was applied to 60 liver biopsies obtained from Egyptian patients with chronic HCV hepatitis in an attempt to: assess the tissue localization of HCV RNA in the liver and to investigate its relationship to the liver pathology, serum level of alanine transaminase (ALT) and viral load in the serum. No similar studies have been reported from Egypt, which is an area of high HCV...
Hepatoprotective and some haematological effects of Allium sativum and vitamin C in lead-exposed Wistar rats
March 2009
The hepatoprotective and some haematological effects of Allium sativum (Garlic) and vitamin C were studied on experimental rats that were exposed to lead (Pb) for one week. Twenty – four female Wistar rats were divided into four groups of six rats per group. Rats in group A were kept as the control. Rats in groups B, C and D were exposed to 100 µmol/kg body weight of lead acetate intraperitoneally...
Multi-drug resistant Staphylococcus aureus in clinical cases in Ile-Ife, Southwest Nigeria
March 2009
A study to investigate the susceptibility pattern of Staphylococcus aureus to conventional antibiotics being frequently prescribed in Ile-Ife, South Western Nigeria was carried out. One hundred and seven samples from various clinical samples were collected from Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. The isolates of S. aureuswere characterized and identified...
Serum total cholesterol in hypertensive Northern Nigerians
March 2009
Hypertension is associated with several lipid abnormalities including elevated total cholesterol (TC) concentrations. The presence of dyslipidaemia increases risks of cardiovascular morbidity and mortality. There is paucity of data on the pattern of serum TC in hypertensive patients in northern Nigeria. The objective of the present study was therefore to evaluate serum total cholesterol in hypertensive...
Antibiotic susceptibility and plasmid pattern of Pseudomonas aeruginosa from the surgical unit of a university teaching hospital in north central Nigeria
March 2009
This study determined the susceptibility pattern and multiple antibiotic resistance (MAR) index of 92 Pseudomonas aeruginosa strains from clinical samples comprising mainly urine (51.1%) and wounds (41.3%) obtained from the surgical units of Ahmadu Bello University Teaching Hospital, Zaria, Nigeria; over a 24-month period. The strains were susceptible to imipenem (94.6%), ciprofloxacin (90.2%), amikacin...
Hepatocellular carcinoma: Risk factors, pattern of presentation and outcome in a tertiary health facility
March 2009
Hepatocellular carcinoma is the fifth most common cancer in the world. Its incidence is increasing worldwide ranging between 3 and 9% annually. The aim of this study was to see the pattern of clinical presentation, identify the possible risk factors and the clinical outcome among HCC patients presenting at our health facility. The case records of all patients with histopathological diagnosis of HCC within the...
Effect of metformin and folic acid on plasma homocysteine level in type 2 diabetic patients
March 2009
Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease in diabetic patients. The aim of this study was to evaluate effects of metformin and folic acid on plasma homocysteine level in diabetic patients. In this clinical trial 47 new cases of type 2 diabetes were randomized to two groups. We treated patients in trial group with metformin and 1 mg folic acid, whereas patients in control group...
Granulomatous inflammation in lymph nodes draining cancer: A coincidence or a significant association!
February 2009
Granulomatous inflammation is considered to be an immune mechanism against infections or certain non-neoplastic conditions. Rarely granuloma formation may be noted in neoplastic disorders also. However a granulomatous response in the lymph nodes draining cancers is unusual. Such granulomas may sometimes show tumour cells in their centre. The exact cause of this phenomenon is not known but an immunologic reaction to...
Bacteriology of automobile accident wounds infection
February 2009
Purulent materials were collected aseptically with the aid of sterile swab sticks from Forty (40) patients with automobile accident wounds at University of Uyo Teaching Hospital (UUTH) and James Accident and Bone Victim Hospital (JABH) in Uyo. These samples were examined microbiologically for the presence of aerobic bacteria and the susceptibility of these organisms to different conventional antibiotics was assessed...
Isolation and characterization of a new chalcone from the leaves of Heteropyxis natalensis
February 2009
Chromatographic analysis of the defatted dichloromethane extract of the leaves ofHeteropyxis natalensis afforded the isolation of (E)-1-(2’,4’-dihydroxy, 5’-methoxy, 3’-methylphenyl)-3-phenylprop-2-en-1-one (R1 = Me; R2 = OH; R3 = OMe; R4 = H) a chalcone. The structure of this compound was established by its spectroscopic data-1D, 2D-NMR, EIMS and HR-EIMS. Key...
Biofeedback application for somatoform disorders and attention deficit hyperactivity disorder (ADHD) in children
February 2009
Biofeedback is a modern computer-related technique used mainly for assessment and therapy of psychophysiological disorders. The influx of about 800 patients per year with stress related disorders is the cause of extensive clinical use of biofeedback in our Department. In this article some results obtained with electrodermal (EDR) and electroencephalography (EEG) biofeedback in the assessment and therapy of children with...
Diagnostic modeling with differences in plasma amino acid profiles between non-cachectic colorectal/breast cancer patients and healthy individuals
January 2009
Metabolic changes in patients with cancer lead to alterations in their amino-acid balances. Thus, amino-acid profiles may be useful as biomarkers of cancers. This study was conducted to analyze amino-acid profiles in plasma by multivariate analysis, in order to elucidate differences between cancer patients and controls. Venous blood samples were taken from colorectal and breast cancer patients, and healthy controls....
Association of angiotensin converting enzyme gene I/D polymorphism with vitiligo in South Indian population
January 2009
Vitiligo or leukoderma is a chronic skin condition that causes loss of pigment due to destruction of melanocytes, resulting in irregular pale patches of skin. Vitiligo is polygenic disease and associated with autoimmunity. Angiotensin converting enzyme (ACE) is capable of modulating cutaneous neurogenic inflammation. An insertion/deletion (I/D) polymorphism of a 287-base pair repetitive sequence in intron 16 of the ACE...
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