Serum protein fractions evaluation in blood donors in Ouagadougou, Burkina Faso
April 2024
To contribute to the assessment of blood donor health at the Regional Blood Transfusion Center of Ouagadougou (CRTSO), we evaluated serum protein fractions in voluntary blood donors. The study included individuals deemed fit to donate blood after a pre-donation medical interview at the CRTSO. Data, including blood grouping and serology results (HIV, HBV, HCV and syphilis) were collected during the pre-donation medical...
Effect of shaking in the production of highly soluble powder from tomatoes using microbial enzyme preparation
March 2024
In this study, functional food ingredients have been developed from tomatoes. Specifically, this paper investigates the possibility of producing tomato powder with high solubility by decomposing (saccharification) the cellulose contained in tomatoes using three different microbial enzyme preparations. Additionally, the paper examines the differences in the concentration of sugar produced with and without shaking during...
Hyperhomocysteinemia in a population of type 2 diabetics in Senegal
February 2024
The objective of this study is to estimate the prevalence of hyperhomocysteinemia in a population of type 2 diabetics and to study the relationship between serum homocysteine ??levels and sociodemographic, clinical and biological characteristics in this population. This is a cross-sectional study involving 100 type 2 diabetic patients. Each patient underwent a routine biological assessment and a total homocysteinemia...
Effect of conditions in the production of highly soluble powder from tomatoes using microbial enzyme preparation
February 2024
This study develops functional food ingredients made from tomatoes. In particular, the cellulose contained in tomatoes was saccharified using microbial enzyme preparations, and the possibility of producing highly soluble tomato powder was investigated. First, the study investigated the conditions for saccharification of Avicel using enzyme preparations A, B and C. A result of saccharifying tomato powder under best...
Biochemical exploration of pancreatic function in market gardeners exposed to pesticides in Bobo-Dioulasso, Burkina Faso
July 2023
Market gardeners use pesticides that could contain disruptors affecting pancreatic function. The objective was to explore exocrine and endocrine pancreatic functions in market gardeners exposed to pesticides. This prospective study was conducted on a cohort of 50 market garden producer participants. Sociodemographic and clinical variables, as well as information on pesticides used, were collected alongside blood...
Physicochemical properties and fatty acid composition of freshly prepared palm oil
July 2023
Elaeis guineensis commonly known as the African palm oil, a monocotyledon widely used due to its nutritional and economic importance. The effect of deterioration of the harvested palm fruit on the physicochemical properties and fatty acid composition of palm oil was investigated. The palm fruit was processed after each period of deterioration (fresh, 7, 14 and 21 days after harvest) for oil production. AOAC Standard...
Fermented mixture of cassava roots and palm kernel cake can substitute for maize in poultry feed formulation
March 2023
A feeding experiment was conducted to investigate the effect of feeding fermented cassava-palm kernel cake (PKC) on weight gain in broiler finishers. Twenty-five 25-day-old chicks were used and divided into five groups. Each group was fed a different diet with varying ratios of maize to cassava roots-palm kernel cake (PKC). The study found no significant difference in weight gain between birds fed fermented cassava...
Effects of Quantitative Trait Loci (QTLs) of BCL11A and HBS1L-MYB genes on clinical-biological variability of sickle cell disease in a Senegalese pediatric population
November 2022
High levels of hemoglobin F (HbF) could reduce the severity of sickle cell disease (SCD) by inhibiting hemoglobin S (HbS) polymerization. HbF expression is modulated by the Quantitative Trait Loci (QTLs) located on the HBS1L-MYB intergenic region (HMIP) (rs28384513) and intron 2 of the B-cell lymphoma/leukemia 11A (BCL11A) gene (rs4671393, rs1427407). To assess the impact of QTLs of HbF on clinical and biological...
Physicochemical parameters of Blighia sapida (K.D. Koenig) oil extracted in Togo
November 2022
Oils extracted from Blighia sapida fruits are usually consumed without any information on its chemical composition. However the bad quality of oil can be a source of toxicity. Thus, the aim of this study is to investigate the physicochemical quality of the oil extracted from B. sapida from Togolese flora. To reach the goal of the study, mature and immature of B. sapida arils were used for oil extraction by the solvent...
Investigation into the intake of a popular polyherbal drug (Jalin Herbal Mannex Liquid) on selected biochemical indices of male wister rats
October 2022
Jalin Herbal Mannex Liquid (JHML) is a polyherbal formulation from honey, Panax ginseng, Liriosma ovate, and Lepidium mehenil, intended for enhanced sexual performance and improve sperm count in men. JHML was studied via its effect on body weight, biochemical indices and histopathology of the testes. Twenty healthy Wistar rats of 120 -150 g weight were allotted into groups A and B., of ten rats each, group A (control),...
Prevalence and associated risk factors of Vitamin D deficiency in children under five years of age, at the Diamniadio Children's Hospital in Senegal
October 2022
Vitamin D deficiency (VDD) is a public health problem which affects all human beings including dark-skinned subjects. In children, it can cause disabilities associated with skeletal abnormalities such as rickets or stunted growth. VDD is also associated with a significant risk of extra-skeletal, infectious, auto-immune, neoplastic, and cardiovascular diseases. The concentration of 25 (OH) D is currently considered as...
Antioxidants and antigenotoxic properties of Rhizopus oligosporus fermented cassava (Manihot esculenta Crantz)
September 2022
The antioxidant and antigenotoxic effects of solid state fermented cassava (Manihot esculenta Crantz) using Rhizopus oligosporus were investigated. Solid state fermentation was carried out for 72 h at room temperature under acidic and basic conditions. Total phenolic content was significantly (p<0.05) higher in fermented peeled and unpeeled cassava at pH 7 and 5 when compared with unfermented. Similarly, the total...
Properties of antioxidants produced by Rhodobacter sphaeroides
May 2022
This study investigated the properties of antioxidants produced by Rhodobacter (R.) sphaeroides, a purple, non-sulfur photosynthetic bacterium. R. sphaeroides was fractionated into water-soluble and ethanol-soluble fractions, and the ethanol-soluble fraction showed stronger activity. Light irradiation significantly decreased the antioxidant activity of the ethanol fraction. The absorption spectra of the ethanol fraction...
Changes in lipid class and fatty acid composition during the development of African pear (Dacryodes edulis) fruit pulp
January 2022
The pulp of the African pear (D.edulis) fruits were investigated for its oil compositions, major lipid classes and constituents fatty acids from 4 weeks after anthesis (WAA) to fruit maturation. The oil was extracted with n-hexane using soxhlet extractor and characterised by gas chromatography. Fatty acid profile showed a saturated acid content of between 19.5 and 36.5% and unsaturated fatty acid content of 63.5...
Amino acids and carbohydrates composition in breast milk of lactating mothers of different age group from Aleto Health Center, Rivers State
January 2022
Breast milk is the white liquid produced by women to breast-feed their babies. It has many benefits for infants, including reduced risk of gastroenteritis and respiratory infection. This study investigated the amino acids and carbohydrates composition in breast milk of lactating mothers. Eighteen (18) lactating mothers between the ages of 16-45 years participated in this study. Amino acid content was analysed with...
Medicinal effects of Saffron on obese animals by reducing Castelli’s risk index to protect from cardio-pathology and psychological distress
January 2022
A high-fat diet is a major factor to the global obesity and diabetes epidemic. The mechanism underlying chronic fat-rich food exposure may raise cholesterol and inflammatory mediator levels. One of the key pathological hallmarks of cardiovascular disorders is the development of inflammatory markers (CVDs). The pathological action may also inhibit the insulin secretion, which triggers diabetes-associated psychological...
The anti-inflammatory activities of twelve Nigerian medicinal plants: Inhibition of NfkB, activation of Nrf2, and antioxidant content
January 2022
Chronic non-communicable diseases are responsible for a large majority of deaths worldwide. These include cardiovascular and respiratory diseases, diabetes and cancer. Inflammation has been reported to be involved in the initiation or progression of these conditions. Populations in developing or low to middle- income countries often rely on traditional medicine using locally available herbs and plants for their medical...
Study of isoforms of nicotinamide adenine dinucleotide phosphate oxidase of the heart in a model of rats fed on several vegetable oils
October 2021
Palm oil has long been incriminated in obesity, and this obesity would be responsible for the development of cardiac fibrosis, several authors have evoked the role of free radicals in the pathophysiological mechanism of the fibrotic response linked to obesity; the aim of this study was therefore to evaluate the profile of NOX2 in the development of cardiac fibrosis in rats subjected to a diet rich in the fat of several...
Association of hyperuricemia and metabolic syndrome in type 2 diabetes mellitus patients in Dakar
October 2021
The association between hyperuricemia and metabolic syndrome (MS) has been reported in many studies. The authors performed this cross-sectional study to determine the association between hyperuricemia and the MS among diabetic patients in Dakar. Type 2 diabetic patients received as part of their follow-up at the Marc Sankalé Center of Abass Ndao Hospital in Dakar were enrolled. For each patient, blood samples and...
Profile of CA 15-3 and CEA during breast cancer chemotherapy at Ouagadougou, Burkina Faso
October 2021
Biomarkers are considered as an innovative tool in the diagnosis and follow-up of breast cancer. The aim of the study was to assess the profile of circulating tumour markers CA 15-3 and CEA in patients under chemotherapy for breast cancer in Ouagadougou. This is a prospective cross-sectional study with a descriptive and analytical aims which was done from July to November 2020. Patients with histologically confirmed...
Phytochemical and biological investigations of extracts from the roots of Cocos nucifera L. (Arecaceae) and Carica papaya L. (Caricaceae), two plants used in traditional medicine
July 2021
Cocos nucifera L. (Arecaceae) and Carica papaya L. (Caricaceae) are two plants used to treat several human pathologies such as oxidative stress and inflammatory diseases. The aim of this study is to assess anti-inflammatory activity, antioxidant activity and acute oral toxicity, of aqueous and methanolic extracts from C. nucifera L. and C. papaya L. using appropriate experimental models. The acute oral toxicity test of...
Evaluation of phytochemical constituents, proximate contents and glycemic index of bambara groundnut (Vigna subterranea L. Verdc) varieties grown in Northeastern Nigeria
July 2021
Bambara groundnut (Vigna subterranea L. Verdc) is widely used as a source of food and also has rich fibre and nutritional values. Hence, this research aimed at determining the phytochemical, proximate content as well as glycemic index and glycemic load of four varieties of Bambara groundnut found in Alkalere area of Bauchi State northeastern Nigeria for possible nutritional and medicinal utilization. Seeds of Bambara...
Serum lipid profile based on the prandial state among adult subjects
July 2021
This study was aimed to access the variations in serum lipid parameters based on the prandial state of adult patients. Through a cross-sectional descriptive and analytical study conducted in Parakou (Benin), from February 1 to May 1, 2020, 100 adult subjects (average age 31.21±12.36 years) were selected with systematic census. After ethical advice, a first sample was taken on empty-bellied adult subjects. Then,...
Influence of the genetic polymorphism of haptoglobin in the occurrence of retinopathy and nephropathy in diabetics subjects
January 2021
The objective of this study was to determine the frequency of haptoglobin (Hp) genotypes and their association with nephropathy and retinopathy in diabetic subjects. This is a case-control study conducted in diabetic subjects developing nephropathy and/or retinopathy. Each patient was matched to a control of the same sex and the same age ± 2 years. Hp genotyping was performed by conventional PCR without enzymatic...
Sphenostylis stenocarpa (Hochst. Ex A. Rich) and fermented Parkia biglobosa ((Jacq, R.B.R.) supplementation prevents high fat diet induced derangements in kidney of albino rats
January 2021
Prevalence of obesity is on the increase globally with high fat diet (HFD) known to be the main contributing factor. This study was carried out to determine the actions of fermented Parkia biglobosa (Iru) and Sphenostyles stenocarpa (Otili) on the kidney of obese induced albino rats. The rats were grouped into a control group fed with normal rats chow and three different high fat diet groups (HFD1, HFD2, HFD3) mixed...
Sub-acute and protective effect of Cymbopogon citratus against carbon tetrachloride-induced liver damage
October 2020
The study evaluates the sub-acute toxicity and antioxidant potential of ethanolic leaf extract of Cymbopogon citratus against CCl4-induced toxicity in Sprague Dawley rats. The ethanolic leaf extract of C. citratus was prepared by solvent maceration method. The phytochemicals present in the extract were determined using standard methods. The potential sub-acute toxicities were evaluated using OECD procedure. The...
Antimalarial pyronaridine resistance may be associated with elevated MDR-1 gene expression profiles but not point mutation in Plasmodium berghei ANKA isolates
October 2020
The selection of resistance is inevitable whenever chemotherapy is necessary for pathogen control. Notably, Plasmodium falciparum has developed multifaceted means to overcome the toxicity of nearly all antimalarial medicines. To bypass this challenge, not only should novel drugs be developed, but the resistance mechanisms to new and existing drugs need should be fully explored. Pyronaridine is a companion drug in...
Insulin resistance and specific biomarkers in blood and urine of type 2 diabetic patients with or without nephropathy in Basrah, Iraq
October 2020
Diabetic nephropathy (DN) is a master cause of all surplus death-rate among type 2 diabetes mellitus (T2DM) patients with microalbuminuria. This study aimed to find effective biomarkers for early predicting of DN. Present study included 63 patients with T2DM (31 patients with DN, 32 patients without DN) and 33 healthy controls. These three groups were matched for their glucose, urea, creatinine, insulin, L-Carnitine...
Correlation between glycated hemoglobin and venous blood sugar in diabetic patients monitored in Abidjan
October 2020
The aim of this study was to determine the correlation between glycated hemoglobin and blood sugar levels in diabetic subjects carried out in Abidjan. This cross-sectional study included 100 patients with diabetes monitored, for three months, for whom glycated blood glucose and hemoglobin were performed, this after informed consent of the patients. Pearson and Spearman correlation tests were used, at the 5% threshold....
Evaluation of acute oral toxicity, hemato-biochemical activity and physiological responses of rabbits and rats administered Moringa oleifera leaf extract and meal
October 2020
The present study aims to evaluate acute oral toxicity of leaf extract of Moringa oleifera and determine the effect of the leaf’s meals of this plant on hematological and biochemical parameters of the rabbit. Ten rats weighing 150 ± 200 g were used for the oral acute toxicity study. Five rats received orally a single dose of 2000 mg/kg of weight of aqueous extract and 5 rats used as control....
Study of the nutritional values and sanitary quality of soumbala collected from six regions of Burkina Faso
July 2020
Soumbala is regularly consumed as a condiment in most households in Burkina Faso. The purpose of this study was, therefore, to assess its nutritional and sanitary quality. To achieve this purpose, samples of sombala have been analysed for the determination of pH, water and ash contents, biochemical parameters, mineral elements, and aflatoxin contents. Results showed that Fada N’Gourma soumbala had the highest...
Antibacterial activity of endophytic fungi isolated from leaves of medicinal Plant Leucas martinicensis L. growing in a Kenyan tropical forest
July 2020
Infectious diseases are major threat to public health; a problem that has been exacerbated by emergence of multi-drug resistant (MDR) strains. Finding alternative antimicrobial compounds from natural sources such as fungal endophytes and medicinal plants is crucial for addressing antimicrobial resistance. Thus, in this study search for endophytes with antibacterial activities from leaves of medicinal plant Leucas...
Inhibitory potential and antidiabetic activity of leaf extracts of Vitex doniana
July 2020
Pancreatic alpha (α)-amylase and intestinal α-glucosidase involved in the enzymatic breakdown of dietary carbohydrates are implicated in postprandial hyperglycemia. The inhibition of these two enzymes has been exploited in the design of antidiabetic drugs. This study was therefore designed to investigate the ability of the leaf extracts of Vitex doniana to inhibit α-amylase and α-glucosidase as...
Evaluation of the effects of Azadirachta indica leaf on haematology, lipid profile, body weight and organ-system functions of streptozotocin-induced diabetic male rats
July 2020
This study was carried out to evaluate the effects of ethanol extract of Azadirachta indica leaf on haematological parameters, lipid profile, body weight, organ weight and histopathological functions of streptozotocin-induced diabetic rats. Diabetes was induced by a single intraperitoneal administration of streptozotocin (50 mg/kg bw.). The haematological parameters, lipid profile and histopathological investigations...
Evaluation of in vivo toxicity of rice husk used as fuel for cooking in households
May 2020
This study aimed to evaluate the toxicological effect of food cooked or water boiled with a fan-assisted top-lit-updraft rice husk fuelled gasifier stove named Paul Olivier 150 (PO150). Distilled water was boiled for 1 h using this stove in an opened pot and closed room. This water was then cooled to room temperature before being administered to rats with body weights ranging from 70 to 110 g. Two types of tests were...
Vitellaria paradoxa fruit pulp bioethanol production potential: A review
May 2020
In the last decade, bioethanol has become a powerful biofuel for the improvement of environmental pollution such as reduction in greenhouse gas levels. Yet, the source and type of substrate material plays a crucial role in the bioethanol production process due to the different compositional characteristics and availability of monomeric sugars. Different substrates of first, second and third generation fuel sources exist...
Study of some biochemical parameters of the seeds of the fruit of the sweet Maniguette (Aframomum alboviolaceum (ridl.) k. Schum.) harvested in the Republic of the Congo
January 2020
Aframomum alboviolaceum is a plant that belongs to the family of Zingiberaceae, genus Aframomum and species of A. alboviolaceum. It is wide spread across tropical Africa and represented about 50 species. Proximate analysis is usually done to determine the values of macronutrients present in plant or food sample; it gives the composition of the biomass in terms of gross components. Proximate analysis includes...
Lambda-Cyhalothrin induced hepato-nephro toxicity potentials and post treatment recovery in Clarias garipinus
January 2020
This evaluates the 28-day toxicity and 7-day post treatment effect of LCT on the behaviour, liver and kidney of Clarias gariepinus. Prior to the experiment, fishes were acclimatized for two weeks. 120 fishes of standard length (SL) / weight (W) 10-12 cm, 8 - 17 g were used for median lethal concentration (LC50) test and 120 fishes of SL / W 16 - 40 cm, 200 - 250 g were used for the behavioural, hepato - nephrotoxicity...
The effect of aqueous extract of zest of citrus sinensis (AEZCs) on cadmium chloride induced liver toxicity in wistar rats
January 2020
The potency of the peels of Citrus sinensis against cadmium induced liver damage has not been explored in our environment. 48 wistar rats were used for this study. The animals were randomly divided into eight (8) groups of five (5) rats each. Group A was the positive control and received 5 mg/kg body weight (bw) of cadmium chloride (CdCl2) intraperitoneally as a single dose. Groups B and C received the aqueous extract...
Prevalence of dyslipidemia in a Burkinabe military population
January 2020
The objective of this study was to determine the prevalence of dyslipidemia in soldiers received at the laboratory of the Medical Center Camp General Aboubacar Sangoulé Lamizana (CMCGASL) for a medical visit. This is a prospective study of 224 military personnel assigned to peacekeeping missions outside Burkina Faso. The study was conducted over the period of September 2017 to November 2017. Included in the study...
Increased levels of mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2-R) found in serum of patients with breast cancer
December 2019
The multifunctional transmembrane mannose-6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2-R) has been proposed as a putative prognostic marker in breast cancer. Loss of heterozygosity (LOH) with mutations in the remaining allele have been described at the gene level. We previously reported significant decrease of M6P/IGF2-R at the protein level in cancer cells than normal peritumoral ducts of breast tumors...
Proximate, mineral and phytochemical compositions of Vernonia amygdalina leaves grown under hot and humid tropical conditions
August 2019
This study was conducted to determine the proximate and phytochemical compositions of Vernonia amygdalina leaves, to ascertain its nutritional potentials. V. amygdalina plants were cultivated, and the leaves were harvested at maturity, cleaned and apportioned into two; one portion was oven dried whilst the other was air-dried- all to a moisture content of about 15%. The dried samples were pulverized and used for...
The pro-oxidant effect of dextran sodium sulphate on oxidative stress biomarkers and antioxidant enzymes in Drososphila melanogaster
July 2019
This study sought to evaluate the behavioural and biochemical effects of Dextran Sodium Sulphate (DSS) on the oxidative stress biomarkers and antioxidant enzymes. Drosophila melanogaster (both sexes) of 3 days old were exposed to various DSS incorporated diets at concentrations, 0.5 - 3.0% for a period of 14 days (Survival rate). The second phase comprised of 3 groups; Group I- Control (normal diet), Group II-0.5% DSS,...
Statistical optimization of L–glutaminase production by Trichoderma species under solid state fermentation using African locust beans as substrate
July 2019
Six strains of Trichoderma species isolated from soil and air samples were screened for extracellular L-glutaminase production. The highest enzyme producing isolate, Trichoderma longibrachiatum was subjected to screening and nutrients optimization experiments under solid state fermentation using a constant weight of African locust beans as substrate. A specific activity of 54.96 U/mg was achieved at 1% (w/v) glutamine,...
Cadmium-induced toxicity and antioxidant enzyme responses in tissues and organs of African catfish (Clarias gariepinus)
June 2019
Juveniles of Clarias gariepinus were exposed to different concentrations of cadmium chloride for 96 h under laboratory conditions using static bioassays with continuous aeration to determine its mean lethal concentration (LC50), biochemical alterations, bioaccumulation and histological pattern in a sub-lethal toxicity test. The median lethal concentration (LC50) at the end of the acute toxicity was 120.2 mgL-1. Also the...
Partial purification of invertase from Momordica charantia (bitter melon) by three phase partitioning (TPP) method
June 2019
The single step three-phase partitioning (TPP) method was evaluated for the purification of invertase from Momordica charantia. Optimum conditions for TPP method, that is, 70% ammonium sulfate saturation, 1:0.5 t-butanol ratio and 30 min incubation time lead to 20.28% efficiency and 10.48 fold partial purification. Total protein decreased from 34.86 mg to 0.68 mg in the homogenate, and the specific activity of the...
Phytochemical, acute and subacute toxicity studies of Annona senegalensis Pers. (Annonaceae) root wood extracts
May 2019
Considered safe because being from natural origin, plant products can exhibit toxic effects during their use. To ensure safe use of Annona senegalensis Pers. (Annonaceae), plant widely used for its therapeutic potential, the phytochemical and safety profiles of its root wood were investigated. Standard tube characterization tests were used to highlight phytochemical groups of root wood of the plant. Acute and subacute...
Immunomodulatory effects of cement in exposed workers
May 2019
This study was conducted to assess the immunomodulatory potentials [immunoglobulin E (IgE), interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α)] of cement dust in individuals occupationally exposed to cement. Potentials of cement particles to modulate immune responses have not been documented in occupationally exposed Nigerians. Twenty-nine male cement loaders who had direct exposure to cement...
Problems of interpretation of serum electrophoresis related to the manual phase during its realization with a semi-automatic automaton
April 2019
Manual steps including preparation of samples and gel, and launching of automatic sequences can cause many difficulties in the interpretation of electrophoresis. Three observations of electrophoretic profiles on Hydragel 15β1-β2 agarose gel media led us to look for interference in the manual step of the technique used. After reconsidering all the steps of the manipulation and carefully observing the profiles...
Association of metabolic syndrome with the risk of developing liver disease in chronic hepatitis B patients
February 2019
Metabolic syndrome is a constellation of abnormal glucose and lipid metabolic parameter that increases ones risk of developing cardiovascular diseases. Metabolic profiles have been linked to progression of varying stages of liver disease in chronic hepatitis B infection. The main objective of this prospective cross sectional study was to establish a link between metabolic syndrome indicators and markers of progression...
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