Typhoid fever commonly called typhoid is a bacterial infection caused by Salmonella typhi. Treatment is by the use of antibiotics which presents other challenges such as drug resistance, high cost of medication and less accessibility to the rural population. The aim and objective of this research was to identify the bioactive metabolites of the leaf of T. occidentalis, determine the antimicrobial activities.on Salmonella typhi. The antibacterial activity of the leaf extracts (aqueous maceration, decoction, infusion and ethanol maceration) of Telfairia occidentalis (Fluted pumpkin or gourd) on Salmonella typhi, was determined using the agar well diffusion technique to investigate its potential use as anti-bacterial agent. The phyto-chemical constituents, Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the leaf were analyzed. The phytochemical analysis of the extracts showed the presence of saponins, flavonoids, tannins, phenolics and coumarin with the absence of phlobatanins and oxalates. The decoction of the leaves demonstrated the highest activity against S. typhi (15+/-2.7mm) at 1000mg/ml. MIC for aqueous maceration, infusion, and decoction was recorded at 62.5mg/ml and that of the ethanol maceration was at 15.625mg/ml. The result of this study suggests that the leaf extract has an insignificant activity on Salmonella due to the extremely high concentration of the extract required to achieve activity.

Keywords: Phytochemical characterization, antisalmonella, Telfairia occidentalis, Cucurbitaceae, Salmonella typhi,