Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3832

Review

Metabolic regulation of the artemisinin biosynthetic pathway in Artemisia annua L.

Lixia Zeng1, Min Chen2, Xiaozhong Lan3 and Zhihua Liao1*
1Key Laboratory of Eco-environments in Three Gorges Reservoir Region (Ministry of Education), Laboratory of Natural Products and Metabolic Engineering, Chongqing Engineering and Technology Research Center for Sweetpotato, Chongqing Sweetpotato Research Center, School of Life Sciences, Southwest University, Chongqing 400715, China. 2College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. 3Agricultural and Animal Husbandry College, Tibet University, Linzhi of Tibet 860000, China.
Email: [email protected], [email protected]

  •  Accepted: 11 November 2011
  •  Published: 31 January 2012

Abstract

Artemisinin was the most effective antimalarial drug in the world and it was a sesquiterpene lactone extracted from a traditional Chinese medicinal herb, Artemisia annua L., Due to its great antimalarial activity but extremely low content of wild-type A. annua plants, many research groups had focused on enhancing the content of artemisinin in A. annua plants. In this review, it mainly discussed the recent research advances on several different metabolic regulation approaches for enhanced artemisinin production.         

 

Key words: Artemisia annua, artemisinin, metabolic regulation, biosynthetic pathway.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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