Carbon tetrachloride (CCl₄) pharmacological tool was used to produce liver damage in rats. Silymarin (100 mg/kg) and extract of Butea monosperma (shown to be hepatoprotective substances) prevented the CCl₄ induced toxicity. Hydroalcholic extract of the stem bark of B. monosperma was evaluated for its hepatoprotective. This in vitroefficacy was reinforced by a significant dose dependent hepatoprotection (at 100 and 200 mg/kg dose) by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation while it significantly increased the reduced Glutathione levels of tissue in a dose dependant manner. The hepatoprotective activities of the extract are being comparable to standards Silymarin. The results obtained in the present study indicate that stem bark extract of B. monosperma is a potential source of natural hepatoprotective. The hepatoprotective property may be attributed to the antioxidant potential and the phytochemical constituents of the plant. The present study justifies the claim of the native practitioner that the decoction of the plant is useful in treating jaundice and find out the clinical efficacy of the B. monosperma.