African Journal of
Pure and Applied Chemistry

  • Abbreviation: Afr. J. Pure Appl. Chem.
  • Language: English
  • ISSN: 1996-0840
  • DOI: 10.5897/AJPAC
  • Start Year: 2007
  • Published Articles: 368

Full Length Research Paper

Design, synthesis and bioassay of novel metal complexes of 3-amino-2-methylquinazolin-4(3H)-one

Ahmed A. H. Al-Amiery*, Yasmien K. Al-Majedy, Sallal A. Abdulhadi and Ali H. Sadoon
Biotechnology Division, Department of Applied Science, University of Technology, Iraq
Email: [email protected]

  •  Accepted: 04 August 2009
  •  Published: 30 November 2009

Abstract

New ligand 3-amino-2-methylquinazolin-4(3H)-one (L) has been synthesized in good yield by the reaction of anthranilic acid with acetic anhydride then replaced the oxygen with nitrogen of hydrazine. When the ligand react with Co(II), Ni(II) and Cu(II) a new complexes are formed. The chemical structure of all prepared compounds were characterized by FT-IR, elemental analysis, 1H-NNR and UV/visible spectra, moreover determination of molar ratio M:L, molar conductance in D.M.F solution, magnetic moments (μeff.) and determination of metal content M% by flame atomic absorption spectroscopy. The free ligand and their metal complexes have been tested in vitro against a number of microorganisms (gram positive bacteria (Staphylococcus aureus and Bacillus cereus) and gram negative bacteria (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa andProteus vulgaris)) in order to assess their antimicrobial properties. All our complexes showed considerable activity against all bacteria.

 

Key words: Metal complexes, methylquinazolin, anthranilic acid, Bacillus cereus.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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