Full Length Research Paper
Abstract
A growth inhibition effect against four Gram-negative (Pseudomonas aeruginosa, Salmonella typhimurium, Klebsiella pneumoniae and Escherichia coli) and three Gram-positive (Staphylococcus aureus, Bacillus cereus and Enterococcus faecalis) pathogenic bacteria was observed for 19 of 20 tested synthetic compounds (that is seven ï§-aminoethers, nine ï§-aminoalcohols and four allylamines). According to the results, the Gram-negative bacteria were the most susceptible strains toward the tested compounds. In general, the MICs of the active compounds were around 1000 ppm, while the MBCs were around 2000 ppm; however, the allylamine 8a was highlighted for its ability to inhibit E. faecalis at the lowest concentration found in this study (MIC = 125 ppm and MBC = 250 ppm).
Key words: Antibacterial activity, ï§-aminoether derivatives, minimal inhibitory concentration, minimal bactericidal concentration, Lipinski’s rule.
Copyright © 2024 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0