Abstract

Increasing resistance to several antibiotics has crucial importance. Many researchers are trying to discover alternative methods or agents to develop antimicrobial effectiveness. In this study, antimicrobial activities of four diverse synthesized perylene diimides were tested, because they are well known dyes and pigments for useful various applications and also antimicrobial activities. These perylene diimides were determined by using disc diffusion and microdilution methods against 21 microorganisms including three yeast cells. The antimicrobial activity of 1,7-dibromo-N,N’-(L-alanine tert-butylester)-3,4:9,10-perylene diimide (2) have shown effect on Staphylococcus aureus, Streptococcus pyogenes, Bacillus cereus, Corynebacterium sp. and Fusobacterium nucleatum bacteria. In addition, the other perylene diimide, 1,7-dibromo-N,N’-(L-glutamicacid tert-butylester) 3,4:9,10-perylene diimide (1) was only active against S. aureus and B. cereus. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of perylene diimides for these bacteria were determined, respectively. These results are novel about perylene diimides, and further improvements on these first attempts may produce a practically applicable antimicrobial activity.

Key words: Perylene dimide, antimicrobial activity, antibacterial activity