October 2011

Mitogen activated protein kinase Influence the immune response of a prevalent Mycobacterium tuberculosis clinical strain of the Indo-Oceanic Clade

Different strains of Mycobacterium tuberculosis (M. tuberculosis) are known to modify the host immune response in a strain-specific manner. However, studies linking M. tuberculosis strain-specific impact upon the regulation of mitogen activated protein kinase (MAPK)-induced monocyte activation are limited. We have studied the immunomodulation, induced by a prevalent Indo-Oceanic Clade clinical strain S7,...

Author(s): Palaniappan Natarajan, C. Ponnuraja  and Sujatha Narayanan

October 2011

The co-infection of human immunodeficiency virus (HIV) and Mycobacterium tuberculosis among patients seen at the general hospital Umuguma, Owerri, Imo State, Nigeria

In this study, the co-infection of Human Immunodeficiency Virus (HIV) andMycobacterium tuberculosis was investigated among patients.  HIV serology was performed on 100 tuberculosis patients whose sputum samples were AFB positive as tested at the General Hospital Umuguma, Owerri, Imo State, between 2nd May 2010 and 3rd February 2011. Seven (7.0%) of the 100 tuberculosis patients were HIV seropositive.  HIV...

Author(s): Opara, Ambrose Uche, Nnodim, John-Kennedy and Okorochi Enoch C.

October 2011

Treatment outcome of newly diagnosed sputum positive adult tuberculosis cases in the context of HIV infection

Nigeria is one of the highest burdened tuberculosis (TB) countries and HIV co-infection poses a challenge in the control efforts of the national programme. Treatment outcome in newly diagnosed smear positive pulmonary TB cases, associated factors and outcome in relation to HIV infection were determined. A 5-year retrospective cross sectional study was carried out on category 1 TB cases at the University College...

Author(s): Olusoji M. Ige and Regina E. Oladokun