January 2011
Evolutionary analysis of gorilla, chimps and humans using sequence divergence
We have analyzed the sequence divergence amongst the three species that is, gorilla, chimpanzee and human varying from Hominidae and Pongidae. Apart from the genomic phylogeny, we compared the protein and rRNA phylogenies to increase the importance of phylogenetic analysis. The proteins selected are from the mitochondrial origin as mtDNA which codes for mitochondrial proteins, mutate at a higher rate compared...
January 2011
Molecular docking of human histamine H1 receptor with chlorpheniramine to alleviate cat allergies
Cat allergen Fel d 1, secreted by the cat’s sebaceous glands and that covers the cat’s skin and fur is the major cat allergen responsible for cat allergies in human. It interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release...
