January 2012

Regulation and properties of glucose-6-phosphate dehydrogenase: A review

Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme of the pentose phosphate pathway that catalyzes the conversion of glucose-6-phosphate to 6-phosphogluconolactone in presence of NADP+. G6PD is an enzyme of vital importance because of its role in various haemolytic disorders and its potential as a regulator for various biosynthetic pathways. NADPH is the important product of the reaction and is used for the...

Author(s): Siddhartha Singh, Asha Anand and Pramod K. Srivastava

January 2012

Detrimental impact of triplet oxygen in biosphere

Oxygen is essential for the existence of all forms of life since it is an important constituent of almost all biologically important compounds including DNA and serves as blood purifier. Simultaneously oxygen also induces a number of degradation processes through the generation of reactive oxygen species like superoxide radical anion, singlet oxygen, hydroxyl radical, hydrogen peroxide etc. The reactive oxygen species...

Author(s): Sunakar Panda