July 2011

Evaluation of the association between ICAM-1 gene polymorphisms and sICAM-1 serum levels in multiple sclerosis (MS) patients in Southeast Iran

Multiple sclerosis (MS) is an autoimmune nervous system disorder characterized by leukocytes recruitment into nervous system and demyelination. Intercellular adhesion molecule-1 (ICAM-1) mediates the extravasation of leukocytes and their accumulation in inflamed tissue. The aim of this study was to evaluate the probable association of ICAM-1 Exon 4 (G241R) and Exon 6 (E469K) gene polymorphisms with circulating levels of...

Author(s): Nima Sanadgol, Abbas Nikravesh, Gholamreza Motalleb, Fariba Roshanzamir, Toktam Balazade, Nourollah Ramroodi and Hamideh Khajeh

July 2011

Five opitz G/B.B.B syndrome cases report with two chromosomal abnormalities; x chromosome duplication (47, XXY) and translocation 46XX t(3q;4q)

Opitz G/BBB syndrome is a genetic condition that affects several structures along the midline of the body. The most common features of this condition are wide-spaced eyes (hypertelorism) with structural defects of the larynx, trachea, and/or esophagus causing breathing problems and difficulty swallowing (dysphagia). Some times in males, the urethra opening on the underside of the penis (hypospadias) is observed. Mild...

Author(s): Juan Manuel Aparicio-Rodríguez, Ma. De Lourdes Hurtado-Hernandez, Isabel Marroquín-Garcia, Guadalupe Araceli Rojas-Rivera, Patricia Sánchez-Meza, Salvador Rodríguez-Peralta, Rigoberto Zamudio-Meneses, Walter san Martin-Brieke, Eduardo Urzaiz-Rodriguez and Enrique Huitzil-Muñoz