January 2010

Genetic polymorphism of kappa-casein gene in indigenous Eastern Africa goat populations

Indigenous goat breeds kept by majority of smallholder rural farmers in Eastern Africa are adapted to the local environment. These goats are critical for nutrition and income of their keepers. Milk production per doe is extremely variable. The variation in milk yield in goats is due to varied management practices and variability in genetic make-up of the animals. The variation in kappa-casein gene and the distribution...

Author(s): S. K. Kiplagat, M. Agaba, I. S. Kosgey, M. Okeyo, D. Indetie, O. Hanotte and M. K. Limo

January 2010

Genotyping of tamoxifen metabolizing enzyme (CYP2D6*4) and its clinical impact in breast cancer patients

Tamoxifen is a non-steroidal antiestrogen drug widely used in the treatment of breast cancer and metabolized by CYP2D6.  In this study, we compared the patients who were receiving either tamoxifen or other chemo drugs, forming a two-arm study.  We genotyped 140 tamoxifen treated postmenopausal women with breast cancer, 140 non-tamoxifen treated pre and postmenopausal women with breast cancer and 124 controls,...

Author(s): C. Kalyana Kumar, Mohan Reddy, Kaiser Jamil and Mohana Vamsy