August 2008

Repeat-dose effects of Zanthoxylum chalybeum root bark extract: A traditional medicinal plant used for various diseases in Uganda

Zanthoxylum chalybeum is a traditional medicinal plant used in the treatment of various ailments in the African region. In sickle cell disease a decoction of the root bark extract is administered for life. The safety of long term use of this plant is not documented. This study investigated the systemic effects of daily administration of low and high oral doses of the root bark extract of this plant in rodents....

Author(s): Ogwang P. Engeu, Tumusiime Ralph, Agwaya Moses, Mugisha Gerosome, Grace Nambatya Kyeyune, Galiwango Badru and Waako Paul

August 2008

Evaluation of the effect of colloidal silver on the antibacterial activity of ethanolic extract of the lichen Parmelia Perlata

Substances extracted from lichens have previously been reported to possess antimicrobial activities against various groups of bacteria, fungi and viruses. Due to the high abundance ofParmelia perlata in the Eastern parts of Nigeria, we decided to explore the effect of colloidal silver on the antibacterial activity against Staphylococcus aureus. The lichen extract was obtained via cold maceration with...

Author(s): Momoh, M. A. and Adikwu, M. U.

August 2008

Synthesis, antiviral and cytotoxic activities of some novel 2-Phenyl-3-Disubstituted Quinazolin-4(3H)-ones

The 2-phenyl-benzoxazin-4-ones were condensed with primary amine to form the 2,3-disubstituted quinazolin-4(3H)-ones. Their chemical structure was elucidated by means of spectral (FT-IR, 1H-NMR, MS) and elemental analysis. The antiviral activity and cytotoxicity of the compounds were tested in HeLa cells (vesicular stomatitis virus, Coxsackie virus B4 and respiratory syncytial virus), HEL cells [herpes simplex...

Author(s): Periyasamy Selvam, K. Babu, R. Padamraj, Leentje persoons and Erik de Clercq

August 2008

Gender independent pharmacokinetics of levofloxacin in healthy black African subjects

The pharmacokinetic profile of levofloxacin in healthy black African subjects as well as the influence of gender on its pharmacokinetic parameters was investigated. Sixteen healthy adult volunteers (8 males and 8 females) enrolled in the study and took single oral dose of 500 mg levofloxacin (LevofloxÒ) after informed consent. The blood of the volunteers was withdrawn from their antecubital vein at 0, 0.25, 0.5,...

Author(s): Mbang A. Owolabi, Grace E. Ukpo, Martin E. Okenne, Olayinka O. Oyeniyi, Olajumoke O. Oladipo and Smith I. Jaja