September 2016
Ameliorative effect of grape seed extract on metabolic disorders caused by high fat diet induced obesity in rats by reversing the increase in hepatic miR-33a and miR-122
MiR-33a and miR-122 are major regulators of lipid metabolism in the liver and their deregulation has been linked to the development of metabolic diseases such as obesity and metabolic syndrome. The aim of this study was to evaluate whether the level of miR-33a and miR-122 in rat liver correlate with obesity and potential anti-obesity effect of grape seed extract (GSE) and calorie restricted diet with special emphasis on...
September 2016
Toxicological assessment of the aqueous dried leaf extracts of Senna alata L. in wistar rats
Senna alata is a medicinal plant that belongs to Leguminosae family. Different parts of the plant are used in folklore medicine for curing skin infections, abdominal pain, and gonorrhoea. Despite the use of S. alata in the treatment of various ailments, there is limited or no comprehensive scientific information on the toxicological evaluation of the dried leaf extract in the folklore medicine in Africa. This study...
September 2016
In vitro and in vivo assessment of genotoxic activity of Petiveria alliacea
Petiveria alliacea L. (Phytolaccaceae) is an Amazonian shrub used in traditional medicine for many purposes. This study investigated the genotoxicity of the hydroalcoholic extract of P. alliacea (EHPa). In addition, we conducted pharmacognostic characterization and phytochemical investigation. Phytochemical screening and thin layer chromatography (TLC) were used to determine the chemical composition of the extract....
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