January 2017

Antihyperglycemic and antihyperlipidemic activities of ethanol extract of Ajuga remota Benth (Harmegusa) leaves in streptozotocin induced diabetic rats

The leaves of Ajuga remota benth have been utilized traditionally for the treatment of patients with diabetes mellitus. However, its use has not been scientifically validated. The present study was therefore, aimed to assess the antihyperglycemic and antihyperlipidemic activities of ethanol extract of A. remota leaves in streptozotocin (STZ) induced diabetic rats. Antihyperglycemic and antihyperlipidemic activities of...

Author(s): Freshet Assefa, Daniel Seifu and Eyasu Makonnen

January 2017

Determination of bioactive constituents of Rauwolfia vomitoria Afzel (Asofeyeje) roots using gas chromatography-mass spectrometry (GC-MS) and Fourier transform infrared spectrometry (FT-IR)

Rauwolfia vomitoria Aftzel belong to the family of Apocynacea with a common name serpent wood and Igbo name as akanta. It is used traditionally to treat hypertension and rheumatoid arthritis. The present study deals with GC-MS determination and FT-IR analysis of methanolic root extract of the named plant. Exactly thirty phytochemical constituents have been identified by comparing the chromatogram peek values of unknown...

Author(s): Okereke, S. C., Ijeh, I. I. and Arunsi, U. O.

January 2017

Screening of some pyrazole derivatives as promising antileishmanial agent

Pyrazole derivatives (I-VII) were prepared in good yields using aldol condensation followed by cyclization and were characterized by elemental analysis, IR and 1H NMR spectroscopy. In vitro antileishmanial activity test was conducted using Alamar blue reduction method. The test revealed that the synthesized compounds (except compound IIb) exhibit better antileishmanial activity than the standard drug miltefosine and...

Author(s): Abdu Tuha, Adnan A. Bekhit, and Yimer Seid