August 2016
Peptide hydroxamate derivatives as regulators for insulin receptor signaling and its degradation by zinc metalloprotease in diabetic rats
Insulin-degrading enzyme (IDE) is the major zinc-metalloprotease involved in the cleavage of insulin, β-amyloid protein and mainly contributes to the pathophysiology of type 2 diabetes and Alzheimer’s disease. Therefore, this enzyme is expressed as candidate target for drugs used in the management of diabetes and peptide hydroxamates have been reported recently as inhibitors for IDE. Novel synthesized peptide...
August 2016
GC-MS analysis of esterified fatty acids obtained from leaves and seeds of Triplaris gardneriana Wedd.
Triplaris gardneriana Wedd. belongs to the family Polygonaceae. In Brazil, the plant is known as "Pajéu". The plant has a traditional use in folk medicine for the treatment of some human diseases. In this study, it was realized for first time, the extraction and characterization by gas chromatography–mass spectrometry (GC-MS) of the fixed oils from the leaves and seeds of T. gardneriana collected...
August 2016
Phytochemical and pharmacological screenings of organic crude fractions of Maesa acuminata
The present study is aimed to investigate phytochemical and pharmacological activities of crude organic fractional extracts of Maesa acuminata (MA). Preliminary test for phytoconstituents shows the presence of alkaloid, glycoside, steroids, tannins, saponins and reducing sugars. Fractionation was done by ethanol (leaf: ELMA), chloroform (bark: CBMA) and n-hexane (leaf: HLMA). The crude fractions were then subjected for...
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