Journal of
Cancer Research and Experimental Oncology

  • Abbreviation: J. Cancer Res. Exp. Oncol.
  • Language: English
  • ISSN: 2141-2243
  • DOI: 10.5897/JCREO
  • Start Year: 2009

JCREO Articles

January 2018

The influence of life behaviour, diet, physical activities on the incidence of breast cancer among women attending Obafemi Awolowo University Teaching Hospital Complex, Ile-Ife

The aetiopathogenesis of cancer has been linked to life behaviour in a significant percentage of cases. Overweight, sedentary lifestyle, smoking and the excessive use of alcohol have been shown to play important roles. This study is aimed at determining the effect of life behavioural patterns and diets in the incidence of breast cancer in Nigerians population. A prospective case-controlled study of 125 breast cancer...

Author(s): Arowolo O. A., Olasehinde O., Oyekunle A. A., Adisa A. O., Alatise O.I. and Adesunkanmi A. R. K.

October 2017

Detection of cervical human papillomavirus in women attending for cervical cancer screening by visual inspection in Côte d' Ivoire

Human papillomaviruses (HPV) cause precancerous lesions and cancers of the cervix. In Côte d'Ivoire, cervical cancer screening program based on visual inspection is the gold standard. This study aimed to detect high risk (HR) HPV DNA on women attending cervical cancer screening program based on visual inspection after application of acid acetic and Lugol. From March to December 2015, cervical samples from...

Author(s): Ouattara Abdoulaye, Yeo Alain, Blavo-Kouame E. B., Koffi Tchibeh F., Saraka Nguessan D., Oura Pierre K., Faye-Kette Hortense and Dosso Mireille

May 2017

Retrospective study on gastrointestinal tract tumors in humans in Zaria, Kaduna State, Nigeria

A retrospective study of gastrointestinal tract (GIT) tumors of humans in Zaria was carried out to determine the prevalence rates. Of the 124 human cases recorded in Ahmadu Bello University Teaching Hospital (ABUTH) Zaria, 39 (31.45%) had upper GIT tumors while 42 (33.87%) had tumors located in the lower GIT. All age groups were affected. The risk for developing tumors increased with age in cases studied. The affected...

Author(s): Mbuk E. U. and Amber E. I.

September 2016

Mean platelet volume and mean platelet volume/platelet count ratio as markers for hepatocellular carcinoma in patients with chronic hepatitis C virus related cirrhosis

Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver. The lack of efficient and precise HCC biomarkers prevents early detection resulting in a poor prognosis. Recently, mean platelet volume (MPV) and MPV/platelet count (PC) ratio have been proposed as potential markers of HCC. This study was carried out to verify MPV and MPV/PC ratio in diagnosis of HCC in Egyptian patients with chronic...

Author(s): Khaled Metwaly, Eman Abdel Sameea, Gasser El-Azab, Medhat Assem, Mohamed Abbasy, Talaat Zakareya and Gamal Abo Raia

September 2016

Prevalence of unilateral arm lymphedema among breast cancer patients one year after completing treatment at Cancer Diseases Hospital in Lusaka

Lymphedema of the arm and/or hand is a long-term complication of breast cancer treatment.  Accurate estimates of the incidence and prevalence of lymphedema are lacking, as are the effects of this condition on overall quality of life. The objective of this study was to determine the prevalence of unilateral arm lymphedema among breast cancer patients one year after completion of treatment at Cancer Diseases...

Author(s): Victoria Mwiinga-Kalusopa, Catherine Ngoma

August 2016

Health related quality of life among breast cancer patients with unilateral arm lymphedema at cancer diseases hospital in Lusaka, Zambia

This study aims to determine health-related quality of life (HRQOL) of breast cancer patients with unilateral arm lymphedema one year after completion of treatment at Cancer Diseases Hospital. The study design comprises of a cross sectional study, where we assessed the HRQoL controlling for patient demographics, cancer stages and treatment types. Short form of 36 interview schedule was used to assess HRQol and to...

Author(s): Victoria Mwiinga-Kalusopa, , Catherine Ngoma and Kennedy Lishimpi

July 2016

Immunotherapy against cancer: A comprehensive review

The endeavor of this paper was to review cancer immunotherapy which means the modulating and using of the patient’s own immune system to target the cancer cells rather than using an extrinsic means of therapy. The best way to prevent and remove infections is through the natural 'sterilising' action of the immune response that combines elements of both innate and adaptive immunity to ward off foreign...

Author(s): Minda Asfaw Geresu, Awel Feku Sultan, Seifudin Kassim Ahmed and Gezahegne Mamo Kassa

April 2016

Diallyl disulfide protects against rectal cancer in vivo model of male rabbits: II-Analysis of histological and cytogenetic variations

The present work was conducted to perform a short-term comparative analysis and evaluate the anti-neoplastic effects of diallyl disulfide on rectal carcinogenicity via histopathological changes, chromosomal aberrations, and mitotic index induced by 1,2-dimethylhydrazine on male rabbits (Orectolagus cuniculus). The histological changes that can be seen microscopically showed that 1,2-dimethylhydrazine at the suggested...

Author(s): Tito N. Habib, Mohammed O. Altonsy, Soheir A. Abd El-Raheem and Yassmin R. Bakeer

August 2015

Clinicopathological and survival significance of BAT-25 and BAT-26 instability in breast cancer among Senegalese patients

In some tumors, defects in mismatch repair enzymes lead to errors in the replication of simple nucleotide repeat segments. This condition is commonly known as microsatellite instability (MSI) because of the frequent mutations of microsatellite sequences. The primary aim of this study is to evaluate the clinicopathological and survival significance of BAT-25 and BAT-26 instability, in 60 patients with breast cancer....

Author(s): Fatimata Mbaye, Sidy Ka, Ahmadou Dem, Mamadou Kane and Mbacké Sembéne,

March 2015

Review on vaccine design strategies against cancer

Cancer is a leading cause of death worldwide, resulting in 8.2 million or 14.6% of all human deaths worldwide in 2012. More than 70% of all cancer deaths occurred in low and middle income countries; although the risk of developing/dying from it is still higher in the developed regions of the world, and tobacco use is the cause of about 22% of cancer deaths which is still a major public health problem worldwide that...

Author(s): Yimer Muktar, Negassa Feyissa, Tesfaye Sisay, Teshager Dubie, Jelalu Kemal and Yitagle Terefe

December 2014

Oncogenic human papillomavirus (HPV) in women from Ghana

Gynaecological or cervical cancer remains a significant public health problem worldwide, a situation from which Ghana is not exempt. Human papilloma virus (HPV) is an important agent of pre-invasive and invasive cervical cancer. Currently, over 70 genotypes of the virus have been identified, of which twenty or more have actually been isolated from or are reportedly associated with female genital lesions. Anecdotal...

Author(s): Brandful J. A. M.⊃, Bonney E.Y.⊃, Asmah R. H.⊃ and Apea-Kubi K. A.  

September 2014

Detecting cancer at primary care level in developing nations by involving youth of a country

After witnessing two cancer deaths in my family, I understood how hard it is for a family to bear the loss. So I strongly feel that a planned approach towards prevention and elimination of cancer, and especially lifestyle related cancers, is the need of the hour in developing nations where resources are limited. A large proportion of a nation’s population is comprised of young adults. They can make a huge...

Author(s): Smile Kajal

March 2014

The prognostic value of IgA/[EBNA1+VCA-p18] on survival of nasopharyngeal cancer patients

Undifferentiated (World Health Organization (WHO) 3) type of nasopharyngeal cancer (NPC) is strongly correlated with Epstein-barr (EBV) virus latent infection. Post-treatment viral reactivation is associated with relapsed or recurrence of NPC. Viral activation can be measured indirectly via plasma IgA responses towards EBV proteins such as EBNA1 and VCA-p18. This study aims at determining the prognostic value of...

Author(s): Kartika Widayati Taroeno-Hariadi, Djohan Kurnianda, Jajah Fachiroh, Bambang Hariwiyanto, Sagung Rai Indrasari, Camelia Herdini, Ibnu Purwanto, Salugu Maesadji, Retno Dwi Danarti, Mardiah Suci Hardianti, Ahmad Harijadi and Sofia Mubarika Haryana

March 2014

Effects of omega-3 fatty acids against Ehrlich carcinoma-induced hepatic dysfunction

Omega-3 essential fatty acids (ω-3 FATs); found in the highest concentrations in fish oil, claim a plethora of health benefits. The present study aims to evaluate the biological effects of ω-3 FATs supplementation against Ehrlich carcinoma (EC) induced inflammation, oxidative stress, biochemical and histopathological alterations in the liver tissue of albino mouse. ω-3 FATs were orally administered via...

Author(s): Ussama Z. Said, Neamat H. Ahmed, Amina M. Medhat and Mustafa M. Mustafa

January 2014

Levonorgestrel-releasing intrauterine device for management of tamoxifen-induced menorrhagia in breast cancer patients

This study aimed to evaluate the therapeutic yield of levonorgestrel-releasing intrauterine device (LNG-IUD) for management of tamoxifen induced menorrhagia in women who had mastectomy for treatment of breast cancer. This study included 34 patients who had breast cancer, underwent mastectomy, were maintained on tamoxifen post-operatively for at least 6 months, and had also newly developed menorrhagia throughout their...

Author(s): Mohamed Anwar El-Nory,  Gamal I. El-Habbaa and Gamal Ibrahim Rageh

January 2014

Hypertrophic pulmonary osteoarthropathy as the presenting symptom of non-small cell lung cancer: A case report

Hypertrophic pulmonary osteoarthropathy (HOA) is a disabling condition that may occur secondarily to primary lung carcinoma. Management of joint pain in patients with HOA is challenging, and treatment options are experimental. Here we report an unusual case of HOA in a 54 year-old man who presented with fever, rash and arthralgia as initial symptoms of an underlying non-small cell lung cancer. He did not respond to...

Author(s): Sheila Nguyen and Mehrnaz Hojjati

November 2013

Mapping Angiogenic Cells CD31 (PECAM1) and CD45 in PCa and BPH Biopsies

  Molecular characterization of PCa and BPH using the angiogenic tissue markers CD31 and CD45 to differentiate between the two major types of prostate gland disorders is investigated. 8 clinically characterized biopsies were analyzed at the Histopathology Laboratory of the Ekiti State University Teaching Hospital; the tissue sections were processed for antigen retrieval and were labeled with anti-CD45 and...

Author(s): Adegun P.T, Ogundele O.M, Falode D.T, Taiwo O.J, Ajonijebu D.C, Omoaghe A.O and Kobomoje O.S

November 2013

Solid-phase total synthesis of cyclic pentapeptide Longicalycinin A, by using 2-chlorotrityl chloride resin

Naturally isolated cyclic pentapeptide Longicalycinin A, which showed cytotoxicity to Hep G2 cancer cell line with an IC50 value 13.52 μg/mL, has been successfully synthesized by solid-phase methodology with Fmoc/t-Bu protecting schemes via solution-phase macrocyclization. 2-chlorotrityl chloride resin was used as solid support. Solution phase macrocyclization of linear pentapeptide precursor was carried out by two...

Author(s): Waqar Ahmad, Farzana Shaheen, Yunshan Zhou and Lijuan Zhang

November 2012

A review of clinical trials of chemotherapy for pancreatic cancer

Chemotherapy is playing an important role in treating pancreatic cancer, either when used alone or when combined with surgery and radiotherapy. We summarized 80 eligible clinical trials published from January in 2006 to June in 2011 and discussed the future development of chemotherapy in the treatment of pancreatic cancer. All the clinical trials were divided into 5 groups: single-agent regimen (14 trials), binary...

Author(s): Hui Zhu, Xinwei Wang, Xiagang Luo, Xiang Yu and Chunzhao Yu

November 2012

Erythrina velutina and Bryothamnion seaforthii lectins binding to proteins of primary central nervous system tumors

This research was done to examine the interaction of lectins with glycoconjugates expressed on Primary CNS tumors using lectins from marine algal Bryothamnion seaforthii(BSL) and seeds of Erythrina velutina (EVL) Fluorescein isothiocyanate (FITC)-labeled. Samples of different tumor types obtained from the Neurology Service of Sobral-Brazil were processed for histopathologic...

Author(s): Felipe M. Conrado, Luis E. T. A. Furtado, Alrieta H. Teixeira, Nara L. P. Coutinho, Alexandre H. Sampaio, Benildo S. Cavada, Mirna M. Bezerra, Antonio Alfredo R. Silva, Francisco Cesar B. Barbosa, Hellíada V. Chaves, Gerardo C. Filho and Vicente P. T. Pinto

December 2011

Evidence of a positive correlation between accelerated oestrogen receptor phosphorylation and breast cancer progression

Estrogen receptor beta (ERβ) is predicted to play an important role in prevention of breast cancer development and metastasis. Phosphorylation of Estrogen receptor alpha (ERα) has been proven to be involved in the progression of breast cancer and it is believed oestrogen receptor beta too phosphorylated at multiple sites within the protein upon ligand binding although the exact function of this...

Author(s): Mohamed Fareez Meerasahib and Amer Hamzah Asseri

November 2011

Loss of heterozygosity (LOH) of deleted in colorectal cancer (DCC) gene and predisposition to colorectal cancer: Significant association in colorectal cancer patients of Kashmir

Loss of heterozygosity (LOH) of deleted in colorectal cancer (DCC) gene, a putative tumour suppressor gene has been implicated in development of various cancers. Here we aim to study the frequency of LOH of DCC gene in colorectal cancer (CRC) patients of Kashmir and further to assess any association with etio-pathological factors. Genomic DNA from 80 confirmed CRC tissue samples as well as adjacent normal...

Author(s): Nighat P. Khan, Arshad A. Pandith, Mahboob U. l. Hussain, Adfar Yousuf, Mosin S. Khan, Mushtaq A. Siddiqi, Khrusheed A. Wani and Syed Mudassar

November 2011

Antitumor potential of an acetogenin isolated from the seed extracts of Annona squamosa Linn.

Ethanolic herbal extract residue of the seeds of Annona squamosa Linn. were tested against Dalton’s Lymphoma Ascites (DLA) tumour cells. Then its effect on the increased lifespan of mice with DLA tumour cells was studied. At high and low dosages, it exhibited 66.67 and 56.25% increase in the lifespan. Percentage of haemoglobin (Hb) and red blood cell (RBC) counts of treated were higher than that of...

Author(s): R. M. Ganesan and K. Muthuchelian

October 2011

Preliminary analysis of radiation dose effects to rat femora microstructure using synchrotron radiation computed microtomography

In this work we investigated the consequences of irradiation in the femur of rats to a radiation dose of 5 Gy. Three different sites in femur specimens were imaged using synchrotron radiation microcomputed tomography to assess trabecular bone microarchitecture: head, distal metaphysis and distal epiphysis. Histomorphometric quantification was extracted directly from the 3D tomographic images using synchrontron...

Author(s): Liebert Parreiras Nogueira, Christiano Jorge Gomes Pinheiro, Regina Cély Barroso, Delson Braz, Carlos Eduardo de Almeida, Cherley Borba Andrade and Giuliana Tromba

  • Article Number: 595259A4068

October 2011

Benign breast tumors in Red Sea State, Sudan

The majority of breast tumors are benign. Some of these tumors carry risk that change into cancer. So, it is important to know the different histopathological patterns of the benign breast lesions. This will help in the proper diagnosis of the lesion and build up of potent programs against the cancer. This research classifies benign breast diseases according to their frequency in Red Sea State, Sudan and compares them...

Author(s): Ali K. Ageep

  • Article Number: 243DC2D4073

September 2011

Chronic myeloid leukemia: Attributes of break point cluster region-abelson (BCR-ABL)

Chronic myeloid leukemia is a molecular fault from neoplastic transformation of hematopoietic stem cells. It is elicited by an extensive spectrum of “fused oncoproteins” which are necessitated in the disease refractoriness. It docks a miscellany of fusion transcripts originating from chromosomal rearrangements. Additionally, vulnerability to genomic rearrangements is particularly enhanced in chronic myeloid...

Author(s): Aamir Rana, , Sabir Hussain Shah, Nazia Rehman, Shaukat Ali, Ghulam Muhammad Ali, Shahzad Bhatti, and Ammad Ahmad Farooqi,

  • Article Number: 486B9884060

September 2011

Experimental therapy against ovarian cancer by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) gene driven by human telomerase reverse transcriptase (hTERT) promoter

TRAIL functions as a soluble cytokine killing various cancer cells with limited toxicity to most normal cells. Human telomerase reverse transcriptase (hTERT) promoter is known to selectively drive transgene expression in many human cancer cells. In this study, we aimed to determine whether the hTERT promoter could efficiently mediate more specific TRAIL gene therapy in ovarian cancer cells. We demonstrated...

Author(s): Hongmei Li and Yuecheng Yu

  • Article Number: 6D5B9B04062

August 2011

Primary neuroendocrine carcinoma of the breast: A rare and distinct entity

Neuroendocrine tumor of the breast is a rare tumor that is under diagnosed and treated. This is a retrospective study over three years of neuroendocrine breast carcinoma cases seen at the National Institute of Oncology in Morocco between May 2007 and 2010. We analyzed various characteristics: Patient demographics, histological diagnosis, disease stage, treatment effects and outcome, in 7 non-metastatic...

Author(s): S. Ghanem, H. Kabaj, S. Naciri, M. Glaoui, N. Ismaili, N. Benjaafar and H. Errihani

  • Article Number: ECFA0974038

August 2011

Patient-specific quality assurance for the treatment of intensity modality radiation therapy of nasopharyngeal carcinoma

Nasopharyngeal carcinoma is the most common malignant tumor of the nasopharynx. The aim of this study was to assess and evaluate the significant of performing patient specific quality assurance (QA) for patients diagnosed with nasopharyngeal carcinoma treated with intensity modulated radiation therapy (IMRT). Ten pretreatment IMRT plans were selected for this study. The ten selected plans were treated with the...

Author(s): H. I. Al-Mohammed and F. H. Mahyoub

  • Article Number: 069591F4054

June 2011

Genetic polymorphisms of GSTM1 and GSTT1 genes and endometrial cancer in Basrah, South of Iraq

The genes glutathione S- transferase M1 (GSTM1) and GSTT1 involved in phase II metabolism catalyse glutathione – mediated reduction of exogenous and endogenous electrophiles. A case control study was designed to identify association between polymorphisms at GSTM1 and GSTT1 genes and endometrial cancer risk. Genotype frequencies in 50 patient’s women with endometrial cancer...

Author(s): Adnan Issa Al-Badran

  • Article Number: B134BE24019

June 2011

Down regulation of galectin-3 in primary tumor tissues of breast predict axillary lymph node metastasis

Identification of axillary lymph node metastasis in breast cancer patients is a challenge in routine pathology practice. Serial sectioning and immunohistochemistry is labor intensive and cannot be followed even for sentinel node examination. So identification of a biomarker predicting axillary lymph node metastasis in primary tumor tissue is of great interest. Galectins are a family of low molecular weight...

Author(s): K. Sujathan, Thara Somanathan, Nimi G. K., Preethi Sara George, Elizabeth K. Abraham and P. Remani

  • Article Number: 38EF3464026

April 2011

Imaging modalities in head and neck cancer patients-overview

Accurate staging and timely assessment in head and neck cancer patients is critical for initiating appropriate treatment strategy. Therefore, pre-treatment imaging in diagnosis is of great importance. Computerized tomography, introduced in the early 70s, followed by magnetic resonance imaging, positron emission tomography, refinements in ultrasonography, and advances in nuclear medicine and applications such as sentinel...

Author(s): M. E. Sham and S. Nishat

  • Article Number: 715657D4004

April 2011

Photochemical internalization: Maximizing the potential of siRNA in cancer therapy through spatially and temporally controlled endolysosomal escape

A major obstacle for cancer therapies is the lack of targeted delivery of therapeutics. To compensate, existing drug treatments rely on high dosages and frequent administrations. This results in adverse effects in the patient due to the drugs failure to discriminate between normal body cells and tumor cells. The discovery of RNAi (RNA interference) has radically opened possibilities to the advancement of cancer...

Author(s): Md Iqbal Touhid, B. S.

  • Article Number: 9334E7B4011

February 2011

Long term remission with 6-Mercaptopurine in refractory Evan’s syndrome

The management of Evan’s syndrome remains a challenge and innovative approaches are needed. Initial therapeutic failure, relapses after initial response and refractoriness to treatments are typical. Options for second-line therapy include immunosuppressive drugs, especially cyclosporin or mycophenolate mofetil; vincristine; danazol or a combination of these agents. We report here a long-term remission of...

Author(s): I. Tazi, H. Nafil and L. Mahmal

  • Article Number: 0B114013971

January 2011

The effectiveness of high dose rate brachytherapy using a special applicator set with external beam radiation treatment and chemotherapy followed by surgery as a treatment of adenocarcinoma of the esophagus: A case series of single institution with literature review

Our study looked at patients with esophageal adenocarcinoma treated with high dose rate brachytherapy (HDR-BT) followed by external beam radiation treatment (EBRT) and chemotherapy with and without surgery to find local response using special HDR-BT delivery catheter, Bonvoisin-Gerard Esophageal Applicator (BG Applicator). We reviewed eight patients’ charts with adenocarcinoma of esophagus (Median age = 63.5...

Author(s): Mihir Raval, and Nicolas Zouain,

  • Article Number: 069DB6D3943

January 2011

Correlation between visual inspection of the cervix and pap smear test for cervical cancer screening

Cancer of the cervix, although a preventable disease has remained a common genital cancer in Nigeria, where most women rarely ever undergo cervical cancer screening. The reasons commonly cited in several studies for this abysmal situation are the absence of routine and organized screening programme, lack of knowledge about cervical cancer screening and cost. Visual inspection of the cervix, which is easy to do, cheap...

Author(s): S. U. Mbamara, C. O. Ukah, O. Ikpeze, Okonkwo Jen and  V. Onyiaora

  • Article Number: 884D9E93953

December 2010

Lectins isolated from Brazilian beans as markers of membrane glycoconjugates of human colon cancer cells

TIn this preliminary study the carbohydrate-binding activity of 10 plant lectins from the Diocleinae subtribe Canavalia ensiformis (Con A), Canavalia brasiliensis (Con Br), Canavalia bonariensis (Con Bo), Canavalia grandiflora (Con Gr), Canavalia maritima (Con M), Dioclea grandiflora (DGL), Dioclea guianensis (Dgui), Dioclea virgata (Dvir), Dioclea violacea (Dvio) and Dioclea rostrata (Dros) was studied to determine...

Author(s): V. P. T. Pinto, E. H. Teixeira, A. H. Teixeira, V. A. Carneiro, G. Cristino-Filho, D. Dus, H. Debray, A. H. Sampaio and B. S. Cavada

  • Article Number: BFDC4853562

December 2010

Investigation of breathing maneuvers using free breathing and video biofeedback techniques during radiation therapy treatment for non small cell lung cancer patients

The goal of radiation therapy treatment increases as the breathing motion decreases, which then will lead to desirable and accurate conformal dose distributions for mobile lung cancer tumor. Twelve healthy volunteers of age ranges between 18-63 years, (5 females and 7 males) were randomly selected for the study in the breathing training methods using free breathing and video biofeedback breathing. The free breathing...

Author(s): H. I. Al-Mohammed

  • Article Number: 2159A703584

November 2010

Primary renal plasmacytoma: Case report and literature review

Extramedullary plasmacytoma (EMP) results from uncontrolled plasma cell proliferation and consists of monoclonal plasmacytic infiltration without bone marrow involvement. These tumors occur most commonly in the head and neck region, followed by gastrointestinal tract, central nervous system, thyroid, breast, parotid gland, testis and lymph nodes. Primary renal plasmacytoma is very rare. We report a primary renal...

Author(s): Gui Fen Yang, Hong Zhu, Long Jiang Zhang and Guang Ming Lu

  • Article Number: C10749D3515

November 2010

Epstein Barr virus latent membrane protein-1 (LMP-1) expression and angiogenesis in Indonesian nasopharyngeal carcinoma (NPC)

The pivotal role of Epstein Barr virus latent membrane protein 1 (LMP-1) in angiogenesishas been concluded from several in vitro experiments. However, there were very limited and inconsistent data on the correlation between LMP-1 and angiogenesis from clinical samples. Therefore, we aimed to investigate the correlation between LMP-1 and angiogenesis from Indonesian nasopharyngeal carcinoma (NPC). Forty cases...

Author(s): Mardiah Suci Hardianti, Johan Kurnianda, Harijadi, Kartika Widayati Taroeno-Hariadi, Rizka Humardewayanti Asdie and Bambang Hariwiyanto

  • Article Number: E51D2F93527

September 2010

The popliteal lymph node group as a naturally positioned model for research on lung cancer metastasis

Lung cancer originates so close to the pulmonary veins that penetration into the blood circulation is naturally assured. Despite such excellent hematogenous opportunities, it is the lymphogenous route that brings about centrifugal lymph node involvement as low down as the abdomen. Therefore, it is hypothesized that the more distant popliteal nodes should be purposively harvested ethically, cut...

Author(s): W. I. B. Onuigbo

  • Article Number: D7132D13469

September 2010

Survival disparities in non-small cell lung cancer patients receiving radiation treatment: An investigation of race and gender

Multiple studies evaluating non-small cell lung cancer disparities reveal male gender and African American race as independent predictors for poorer outcome. This study aims to evaluate the prognostic factors affecting survival of non-small cell lung cancer patients receiving radiation treatment at the University of Washington and to investigate whether race and gender disparities persist at the level of access to...

Author(s): Yogesh Khanal, Julie Eaton, Janelle Pakish, Philemon Yen, Renato Martins, Laurie Carr, Keith Eaton and Shilpen Patel

  • Article Number: FF7F44C3482

September 2010

Ultrastructural changes in premalignant and malignant lesions of the uterine cervix with papillomavirus infection

The main purpose of this study was intended to determine the possible ultrastructural relations among the human papilloma virus infection, angiogenesis and cellular infiltrate in premalignant and malignant lesions of uterine cervix. 58 samples of cervix were obtained from patients of the ambulatory “Maria Teresa Toro” Aragua, Venezuela, with cervical intraepithelial neoplasia (CIN) and human papillomavirus...

Author(s): Ivis J. Graterol⊃, Hector J. Finol⊃, Maria Correnti⊃ and Maira Ávila⊃

  • Article Number: 58BA1343496

April 2010

Cerebral leptomeningeal metastasis in a case of primary ovarian lymphoma

A 38 years old female patient is presented who applied to our neurosurgery clinic due to symptoms such as headache, ataxia, vertigo, vomiting and complaints related to a mass at the back side of her head. The examination of cranial magnetic resonance imaging (MRI) of the patient displayed a mass which obliterates the transverse sinus and extends from the scalp to the epidural space at a certain...

Author(s): Nejmi Kiymaz, Nebi Yilmaz, Mustafa Kösem, Taner Yazici, Suleyman Alici and Abdulbaki Kozan

  • Article Number: 72E3F5F3441

April 2010

Long survival in patients with metastatic leiomyosarcoma of the uterine corpus: A report of 2 cases

Leiomyosarcoma of the uterus is relatively uncommon in Ahmadu Bello University Teaching Hospital, Zaria - Nigeria and generally has a poor prognosis. A report of palliative treatment for invasive leiomyosarcoma of the uterine corpus with pulmonary metastases in 2 women is presented. Both patients presented with advanced bulky locoregional and metastatic disease. The patients had palliative care using multimodality...

Author(s): S. A. Adewuyi, M. S. Zayyan, P. I. Onwuhafua, M. O. A. Samaila, A. H.Rafindadi and A. O. Oguntayo

  • Article Number: 7DCDE1E3449

March 2010

An unusual presentation of non-Hodgkin lymphoma

A 49 year old woman was admitted to our hospital with symptoms suggestive of breast cancer. The histological study of the left lumpectomy showed diffuse large B-cell lymphoma of the breast. In addition, the radiological assessment of the disease showed multiple organ involvement by the lymphoma. The patient achieved complete response after 3 cycles of chemotherapy but rapidly developed fatal evolution after the...

Author(s): Nabil Ismaili, Ouafae Bentama and Hassan Errihani

  • Article Number: 6B7A9603420

December 2009

A case of breast cancer found as metastasis to the duodenum

A 58-year-old woman underwent left total mastectomy for invasive ductual carcinoma of the breast in 2002. In November 2007, the upper gastrointestinal endoscopy showed that an ulcer (~ 0.3 × 0.5 cm) was covered with white fur and surrounded by edematus tissue at the anterior wall of duodenal bulb. The follow-up pathological examination revealed that the morphology of the cells of duodenal cancer was identical to...

Author(s): Xiu-wen Wang, Xiang-jiao Meng, Ting-guo Zhang, Lian Liu, Cui-hua Yi, Dong-yan Hu and Shu-guang Li

  • Article Number: 85450571441

December 2009

Silver binding nucleolar organiser regions in oral submucous fibrosis, lichen planus, leukoplakia and squamous cell carcinoma

This study was undertaken to assess the biologic aggressiveness of sub mucous fibrosis, lichen planus, leukoplakia and squamous cell carcinoma of the oral cavity by determining the mean number of AgNORs and comparing them with those of normal mucosa. The study sample consisted of total 93 subjects. Biopsy specimens of 26 squamous cell carcinomas, 22 sub mucous fibrosis, 15 lichen planus, 15 leukoplakia and 15 healthy...

Author(s): Sunita Kulkarni, R. N. Mody, Sanjeev Jindal, Ravinder Singh Sohiand Bhawandeep Kaur

  • Article Number: 9D34B391470

October 2009

Stage dependent expression of MUC1 glycoprotein in gallbladder carcinoma

Gallbladder carcinoma is a relatively aggressive and frequently lethal cancer. It is defined as a clinicopathological presentation including a wide spectrum of lethal disease from simple gallstones to dysplasia, to carcinoma in situ and invasive carcinoma. MUC1, a cell surface antigen expressed in glandular epithelia, is overexpressed and aberrantly glycosylated in adenocarcinoma. In this report, the...

Author(s): K. Sanjeev Maurya, Mallika Tewari, K. Mahendra Thakur, Mohan Kumar, and S. Hari Shukla

  • Article Number: DB0D5C71360

October 2009

In vitro interaction of cyclooxygenase-2 inhibitors with radiation in nasopharyngeal carcinoma cell line: Dependence on sequence of administration

In nasopharyngeal carcinoma (NPC), COX-2 inhibitors have been reported to exhibit dose-dependent growth inhibition of these cancer cells, but their interaction with radiation has not yet been studied.  Here, we examined the effects of selective COX-2 inhibitors SC-236 and NS-398 on the radiosensitivity of NPC cells.  When  incubated  with  COX-2  inhibitors  prior  to ...

Author(s): Melvin  Lee  Kiang  Chua,  Haslinda  Binte  Kamis,  Jonathan  Yi  Hui  Tehand Susan  Li  Er  Loong,

  • Article Number: 9B3CDB51380

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