July 2008

Efficacy and toxicity of cymelarsan® in Nubian goats infected with Trypanosoma evansi

Nine groups of Nubian goats were infected with T. evansi. Groups 1 and 2 were used as negative and positive control respectively, groups 3, 4, 5 and 6 were given a single intramuscular dose of Cymelarsan® at the rate of 0.125, 0.25, 0.625, 1.25 mg/kg, respectively. Goats in groups 7 and 8 were each given intramuscular Cymelarsan® at the rate of 0.125 mg/kg twice/week for two weeks and 0.125 mg/kg...

Author(s): F. M. Youssif, O. S. A. Mohammed and T. Hassan

July 2008

Biochemical changes in the plasma of vervet monkeys (Chlorocebus aethiops) experimentally infected with Trypanosoma brucei rhodesiense

Biochemical evaluation of plasma during disease conditions gives an indication of the functional status of the various body organs. Biochemical analysis of plasma from 32 vervet monkeys (Chlorocebus aethiops) infected with Trypanosoma brucei rhodesiense revealed at various stages of infection, dramatic increases in blood urea nitrogen, triglycerides, cholesterol and tissue enzymes including creatine kinase...

Author(s): Ngure R. M., Ndung’u J. M., Ngotho J. M., Nancy M. K., Maathai R. G., and Gateri L. M.