August 2009
Pharmacoeconomics: An emerging branch in health sciences for decision making
Increasing health care cost is a major concern in the developing world and has increased the individual economical burden for a common man. Patients are affected by the high pricing of drugs and though the symptoms improve, the poor patient’s compliance sets in if the regimen is heavy on his/her pocket. Therefore, the concepts of pharmacoeconomics are essential for physicians to prescribe individualized drug...
August 2009
Safety evaluation of the extract from the roots of Pelargonium reniforme Curtis in male wistar rats
Pelargonium reniforme Curtis is an herb used for the treatment of various human and animal diseases especially in the Eastern Cape of South Africa. The effects of the oral administration of aqueous extract of the plant roots at 100, 200 and 400 mg/kg body weight for 21 days on some haematological and biochemical parameters in male Wistar rats were investigated. Oral treatments with this extract did not cause...
August 2009
Preliminary phytochemical, analgesic and anti-inflammatory studies of the methanol extract of Anisopus mannii (N.E.Br) (Asclepiadaceae) in rodents
The methanol extract of the aerial parts of Anisopus mannii was evaluated for its analgesic and anti-inflammatory activities. The analgesic effect was studied using acetic acid-induced abdominal constriction test in mice, while the anti-inflammatory effect was investigated using carrageenan induced paw oedema in rats. The results of the study showed that the extract (40 mg/Kg) exhibited significant (P <...
August 2009
Pharmacodynamic effect of piperazine citrate on the blood pressure of anaesthetized cat
Piperazine citrate produced a dose-dependent decrease in the blood pressure of the anaesthetized cat. Both 15 mg and 30 mg/kg piperazine showed average significant reduction in blood pressure of 29.8 ± 1.65 and 78.3 ± 3.18 mm Hg respectively. The effect produced in each case was transient and returned to baseline value within 2 min. The reduction in blood pressure caused by piperazine...
August 2009
Hepatoprotective effects of glycine and vitamin E, during the early phase of liver regeneration in the rat
Our objective was to demonstrate the protective effect of glycine (Gly) and vitamin E (VE) on a model of ethanol-induced acute liver injury during the early phase of liver regeneration after partial hepatectomy (PH) in rats. Fifty male Wistar rats (body weight (b.w.), 240 - 280 g) were divided into four groups (n = 10, each, respectively) as follows: 1) control partial hepatectomy (PH), 70%; 2) PH + ethanol (EtOH) at...
August 2009
Ototoxic effects of tuberculosis treatments: How aware are patients?
This project aimed to determine awareness of South African adults with tuberculosis (TB) of the ototoxic effects of TB medication. 60 adults undergoing TB treatment in Gauteng participated. A semi-structured interview schedule was utilized to collect data. Data analysis used descriptive statistics. Results revealed a generalized lack of awareness amongst the participants regarding TB as a disease, its symptoms and how...
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