August 2021

Pharmacokinetics of gallic acid following oral administration of Triphala formulation in rats

Triphala formulation is one of the most common traditional medicines used for several health conditions. The study investigated the pharmacokinetics of gallic acid following an oral dose administration in rats. The pharmacokinetics of gallic acid was investigated in rats following a daily oral dose of 1,000 and 5,000 mg/kg body weight (28 days). Plasma concentrations of gallic acid were measured using liquid...

Author(s): Piracha Jumpa-ngern, Tullayakorn Plengsuriyakarn, and Kesara Na-Bangchang,

August 2021

Bioactive pyrrole-pyrazine derivative from a novel Bacillus species and review of the literature

The rising antibiotic resistance is urging researchers to explore for new forms of antibiotics, notably from soil microorganisms such as Bacillus species. This study aimed to screen Bacillus strains from soil samples in Sudan for antifungal activity and to review relevant compounds from members of the genus in the literature. Out of 10 isolates from soil in Sudan, the strain JS6 (DSM 28831) was found active against...

Author(s): Maria M. Elamin, Nada A. Abdelrahim, Dia Eldin A. Elhag, Martin R. P. Joseph and Mohamed E. Hamid

August 2021

Examining characteristics, knowledge, attitude and practice of pharmacovigilance by health care professionals in Sub-Saharan Africa: A systematic review of the literature

The pharmacovigilance practices aim to improve the safety and care of patient in relation to the utilization of medications, as well as other medical and paramedical interventions. Due to emergence of outbreaks of infections, the sub-Saharan African countries have been widely utilizing the trial drugs, which have been increasing the events of Adverse Drug Reactions (ADRs) in the region. This systematic literature review...

Author(s): Larry L Mweetwa, Thatoyaone J Kenaope, Bonang Mosala, Kenneth Pule, Gerald Juma Obure, Getrude Mothibe, Kabo O. Tshiamo and Emmanuel Tope Oluwabusola

August 2021

Sclerocarya birrea: Review of the pharmacology of its antidiabetic effects and toxicity

Sclerocarya birrea (A. Rich.) Hochst, an African widespread plant is known to be used for type 2 diabetes management in sub-Saharan Africa. This review aims to summarize the findings for the pharmacology of S. birrea antidiabetic effects and its in vivo and in vitro toxicity. To collate data on S. birrea, various scientific search engines like PubMed, Scopus, Scifinder, Google Scholar, Web of Science, Wiley Online,...

Author(s): Abdul Gafar Victoir Coulidiaty, Estelle Noëla Hoho Youl, and Téné Marceline Yaméogo,