November 2015

Comaparative study of the antidiabetic and biochemical effects of metformin, glibenclamide and repaglinide in alloxan- induced diabetic rats

Diabetes mellitus is one of the major global health burden affecting both developed and developing countries. This study examined the antidiabetic effects of metformin (MET), glibenclamide (GLI) and repaglinide (REP) on biochemical parameters in alloxan-induced diabetic rats. The study will assess the efficacy of these standard drugs in managing the complications arising from diabetes mellitus. Alloxan (130 mg/kg BW)...

Author(s): Bonaventure Chukwunonso Obi, Theophine Chinwuba Okoye, Elijah Parker Joshua, Collins Azubuike Onyeto and Edwin Olisah Alumanah

November 2015

Stabilized rice bran extract: Acute and 28-day repeated dose oral toxicity with in vitro mutagenicity and genotoxicity study

The toxicity of Egyptian stabilized rice bran extract (RBE) has been evaluated for acute and repeated 28 day oral toxicity with the outcome of genotoxicity. The extract was administered to female white albino rats at 2000 mg kg-1 for acute testing and to male and female rats at concentrations of 1000, 500, and 100 mg kg-1 for 28 days. Mutagenic potential was evaluated. Chromosomal and DNA damage using standard...

Author(s): Ola A. Heikal, Maha B. Zickri, Amr M. Helal, Hisham El Askary, Bernd L Fiebich and Iman E. O. Gomaa