January 2008

Chromatographic method development: computer simulated statistical design approach

The computerization of method development and validation are useful in analysis of pharmaceuticals in pharmaceutical industry. In this article a simple and rapid high performance liquid chromatographic method has been developed for the determination of oxcarbazipine in pharmaceutical formulations. Factorial design was applied for optimization of essential factors for robustness study. A linear model was postulated and a...

Author(s): Allam Appa Rao

January 2008

Study on QSPR method for theoretical calculation of heat of formation for some organic compounds

Quantitative Structure – Property Relationship (QSPR) models based on molecular descriptors derived from molecular structures have been used for the prediction of heat of formation using a set of 20 organic compounds. The molecular and quantum chemical descriptors used to represent molecular structure include topological indices and constitutional descriptors. Forward stepwise regression was used to...

Author(s): Ashrafi Ferydoun, Rostami Abbas Ali and Mahdavipour Najmeh