March 2014

Usefulness of liver and kidney function parameters as biomarkers of ‘heavy metals’ exposure in a mammalian model Mus musculus

The toxicological evaluations of cadmium (Cd), iron (Fe), manganese (Mn), lead (Pb) and zinc (Zn) were carried out against Albino mice model, Mus musculus. On the basis of LC50 value, Cd (0.47 mM) was found to be the most toxic followed by Zn (2.40 mM), Pb (2.42 mM), Fe (4.52 mM) and Mn (5.70 mM) as least toxic. The results of the sublethal concentration of the heavy metals (1/10th of 96 hrLC50) on the liver function...

Author(s): Osuala Fidelia I., Otitoloju A. A. and Igwo-Ezikpe M. N.

March 2014

Properties of rhodanese from the liver of tilapia, Oreochromis niloticus, in Asejire Lake, Nigeria

The study investigates the purification and characterisation of rhodanese from the liver of the tilapia fish (Oreochromis niloticus) collected from Asejire Lake in Nigeria. This was with a view to understanding the biochemical basis of the survival of the fish in cyanide polluted water. Rhodanese was isolated and purified from liver tissue homogenate of tilapia using CM-Sephadex ion exchange chromatography and Sephadex...

Author(s): Atere Tope Gafar, Ademakinwa Adedeji Nelson and Agboola Femi Kayode