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Comparative studies of the crude extracts of sesame against
some common pathogenic microorganisms
Ahmed, T.3*, Shittu, L. A. J1, Bankole, M.
A.2, Shittu, R. K4, Adesanya, O. A.1,
Bankole M. N.5 and Ashiru, O. A1
1Department
of Anatomy, Lagos State University College of Medicine,
Ikeja, Lagos, Nigeria.
2Department
of Medical Microbiology and Parasitology, College of
Medicine, University of Lagos/Lagos University Teaching
Hospital, Idi-araba, Lagos, Nigeria.
3Department
of Microbiology, Drug Quality Control Laboratory/Lagos State
University Teaching Hospital, Ikeja, Lagos, Nigeria.
4Medical
Microbiology Unit, Bolomedics Laboratories, Egbeda, Lagos,
Nigeria.
5Diarrhea
Unit, Microbiology Division, Nigerian Institute of Medical
Research, Yaba, Lagos, Nigeria.
*Corresponding author. E-mail:
taiahmedy2k4@yahoo.com.
Accepted
19 February, 2007. |
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Concern
about the rising prevalence of antibiotics resistant strains
pathogenic microorganisms has been expressed in the last
three decades. However, intensive studies on extracts and
biologically active compounds isolated from medicinal plants
have equally doubled in the last decade. The ethanolic,
methanolic and aqueous extracts of Sesame radiatum
and its combination with Sesame indicum
leaves were studied for their in-vitro antimicrobial
activity against tested pathogenic micro-organisms. The gas
chromatography-mass spectrometry phytochemical screening
showed the presence of essential oils mainly the phenolic
and carboxylic acids groups. Ethanolic extracts of Sesame
leaves have no inhibitory effects on Staphylococcus
aureus but strongly effective against Streptococcus
pneumoniae and mildly effective against Candida
albicans. However, the methanolic extract exhibited a
mild antimicrobial activity against Staph. aureus and
C. albicans, but no inhibitory effect on S.
pneumoniae. C. albicans was mildly inhibited by
the aqueous extract. However, there was a strong
antimicrobial effect against S. pneumoniae and
Staph. aureus in the combination of aqueous extracts of
both species. The Sesame leaves extracts are equally
effective against tested micro-organisms as the standard
antibiotics.
Key
words:
Pathogenic micro-organisms, anti-microbial, sesame leaves. |
