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Article Number - AD33DA640209


Vol.6(25), pp. 5396-5402 , October 2011
https://doi.org/10.5897/SRE11.763
ISSN: 1992-2248


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Full Length Research Paper

Cytoprotective effects of Bauhinia purpurea leaf extract against ethanol-induced gastric mucosal ulcer in rats


Ismail Ibrahim Latif




Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.


Email: [email protected]






 Accepted: 16 August 2011  Published: 30 October 2011

Copyright © 2011 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Bauhinia purpurea is a medicinal plant commonly used traditionaly in the treatment of many ailments. The present study was undertaken to evaluate the protective effect of ethanolic extracts of B. purpurea ethanolic leaf extract (BPELE) against absolute ethanol-induced gastric mucosal damage in experimental rats. The rats were divided into four groups, respectively pre-treated orally with carboxymethyl cellulose solution (ulcer control groups), omeprazole 20 mg/kg (reference group), 250 and 500 mg/kg of BPELE (experimental groups) 1 h before oral administration of absolute ethanol to generate gastric mucosal damage. After an additional hour, the rats were sacrificed and the ulcer areas of the gastric walls were determined. The ulcer control group exhibited severe mucosal injury, whereas groups pre-treated with B. purpureaethanolic leaf extract exhibited significant protection of gastric mucosal damage. These findings were also confirmed by histology of gastric wall. Significant increases in gastric mucus production and decrease in acidity of gastric content were observed in treated groups with BPELE compare to ulcer control group. These results concluded that the treatment with BPELE prior to absolute alcohol has significantly protect gastric mucosa as ascertained grossly by significant reduction of ulcer area,increases in gastric mucus production and deecrease the acidity of gastric content and histology by comparatively decreases in gastric mucosal damage, reduction or absence of edema and leucocytes infiltration of submucosal layer compared to ulcer control group. BPELE was able to decrease the acidity and increase the mucosal defense in the gastric area thereby justifying its use as an antiulcerogenic agent.

 

Key words: Bauhinia purpurea, cytoprotection, gastric ulcer, mucosal defense, histology.


APA (2011). Cytoprotective effects of Bauhinia purpurea leaf extract against ethanol-induced gastric mucosal ulcer in rats. Scientific Research and Essays, 6(25), 5396-5402.
Chicago Ismail Ibrahim Latif. "Cytoprotective effects of Bauhinia purpurea leaf extract against ethanol-induced gastric mucosal ulcer in rats." Scientific Research and Essays 6, no. 25 (2011): 5396-5402.
MLA Ismail Ibrahim Latif. "Cytoprotective effects of Bauhinia purpurea leaf extract against ethanol-induced gastric mucosal ulcer in rats." Scientific Research and Essays 6.25 (2011): 5396-5402.
   
DOI https://doi.org/10.5897/SRE11.763
URL http://www.academicjournals.org/journal/SRE/article-abstract/AD33DA640209

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