February 2010
Validation and stability indicating RP-HPLC method for the determination of tadalafil API in pharmaceutical formulations
The present study describes the development and subsequent of a stability indicating RP-HPLC method for the analysis of tadalafil. The samples separated on an Inertsil C18, (5 m , 150 mm x 4.6 mm i.d) by isocratic run using acetonitrile and phosphate buffer as mobile phase), with a flow rate of 0.8 ml/min, and the determination wavelength was 260 nm for analysis of tadalafil. The described method...
February 2010
Potential therapeutic interventions on toll like receptors for clinical applications
Toll like receptors (TLRs) function as pattern-recognition receptors (PRRs) and play key roles in the recognition of microbial components or endogenous ligands induced during inflammatory response. Studies on TLR-deficient mice have indicated TLRs' involvement in multiple pathologic conditions, and targeting of either the TLRs themselves or the signals they generate is proving to be of great interest to...
