April 2016

Examination of Candida albicans strains from South Africa for the production of gliotoxin and other cytotoxic secondary metabolites

Candida species cause superficial mycosis and more serious systemic infections. The virulence factors of Candida are their adherence and hyphae formation ability and the production of hydrolytic enzymes. In addition, they produce secondary metabolites which are also implicated in the pathogenesis. Literature on the production of gliotoxin, one of the metabolites by Candida spp. is controversial. The aim of this study...

Author(s): Tshabalala Nhlanhla, Mrudula Patel and Dutton Michael Francis