Journal of
Veterinary Medicine and Animal Health

  • Abbreviation: J. Vet. Med. Anim. Health
  • Language: English
  • ISSN: 2141-2529
  • DOI: 10.5897/JVMAH
  • Start Year: 2009
  • Published Articles: 318

Full Length Research Paper

Decreased level of serum paraoxonase (PON) activity in dogs with dilated cardiomyopathy (DCM)

Mahadesh Prasad AJ*
  • Mahadesh Prasad AJ*
  • Department of Microbiology, Comprehensive Cancer Center, University of Pennsylvania Medical School 201E Johnson Pavilion, 3610 Hamilton Walk Philadelphia.
  • Google Scholar
Monika Krueger
  • Monika Krueger
  • Institute of Bacteriology and Mycology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.
  • Google Scholar
Maxi Krueger
  • Maxi Krueger
  • Institute of Bacteriology and Mycology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany.
  • Google Scholar


  •  Received: 06 July 2011
  •  Accepted: 26 July 2014
  •  Published: 30 September 2014

Abstract

Serum Paraoxonase (PON1) is a high-density lipoprotein associated esterase capable of hydrolyzing numerous organophosphates and protects low-density lipoprotein against peroxidation. PON1 is believed to play a crucial role in the prevention of cardiovascular disease in animals and PON1 activity has been shown to be low after myocardial infarction, liver disease and during oxidative stress. Here in this article we demonstrated that PON1 level is significantly lowered during the dilated cardiomyopathy (DCM) in dogs.  This investigation was carried out on 208 canine serum samples. The serum PON/arylestrase activity was measured in 84 healthy dogs and 124 dogs with dilated cardiomyopathy (DCM) of varying severity. Since heart failure is characterized by oxidative stress, inflammation, deficiency in metabolic substrates and lack of blood supply to heart. Decreased PON activity was significantly observed in advanced stages of DCM.

 

Key words: DCM, Paraoxonase, Phenyl acetate, High-density lipoprotein, NYHA-classification.