January 2016

Abnormality of spermatozoa in Wistar rats exposed to high doses of Valeriana officinalis L. aqueous suspension

Valerian (Valeriana officinalis L.) is a natural anxiolytic widely used in traditional medicine. However reproductive toxic effects have been demonstrated in mice treated with this species. This study evaluated the effect of valerian aqueous suspension on the reproductive system of Wistar rats treated for 53 days. Four groups were studied (n=25): control (1 ml of distilled water) and treated (500, 1000 or 2000 mg/kg)...

Author(s): Renato Macedo Marques, Marcos Antônio Fernandes Brandão, Leonardo Toshio Oshio, Rita de Cássia da Silveira e Sá, Vera Maria Peters and Martha de Oliveira Guerra