Vol.6(43), pp. 5582-5585 , November 2012
DOI: 10.5897/JMPR11.1434 Total Views: 152
ISSN: 1996-0875 Downloaded: 126
Full Length Research Paper
Salud Pérez G1, Linnet Hernández B1, Miguel A. Zavala S1*, Edith Morales G1 and Norma Cardenas2
1Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana Unidad Xochimilco. Calzada de Hueso 1100, Col. Villa Quietud, Coyoacán, C.P. 04960, D.F, México.
2Facultad de Ciencias Químicas, Universidad Autónoma de San Luis Potosí, Av. Dr. Manuel Nava #6 CP. 78290, San Luis Potosí, SLP, México.
Accepted: 09 May 2012 Published: 10 November 2012
Copyright © 2012 Author(s) retain the copyright of this article.
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Anti-inflammatory activity of chloroform and methanol extracts from aerial parts of Hyptis albida was tested on different pharmacological models in rats and mice. The plant was collected in Guadalcazar San Luis Potosí State, dried and powdered. The extracts were obtained by heating the solvent to its boiling point. The extracts free of solvent were tested in two pharmacological models, carrageenan-induced edema and 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced mouse ear edema. In the case of carrageenan model, the extract was administered orally using polyvinylpyrrolidone (PVP) like vehicle and for the TPA, topical administration was used. Results showed that chloroform and methanol extracts had effects on TPA-induced edema, the major effect was observed with the chloroform extract. Also this extract inhibited edema cause by multiple applications of TPA (53.2%). In carrageenan induced edema test, the chloroform extract showed no dose dependent response at doses of 100, 200, and 400 mg/kg. The results suggest that H. albida could be a source for compounds with anti-inflammatory effect.
Key words: Hyptis albida, anti-inflammatory activity, 12-O-tetradecanoylphorbol 13-acetate (TPA), carragenan