Journal of Medicinal Plants Research
Subscribe to JMPR
Full Name*
Email Address*

Article Number - A3BACEF14571


Vol.3(1), pp. 001-008 , January 2009

ISSN: 1996-0875



Full Length Research Paper

Anti-inflammatory activity of brown alga Dictyota dichotoma in murine macrophage RAW 264.7 cells


Weon-Jong Yoon1, Young Min Ham1, Kil-Nam Kim1, Soo-Yeung Park1, Nam Ho Lee2, Chang-Gu Hyun1* and Wook Jae Lee1*




1Research Group for Cosmetic Materials, Jeju Biodiversity Research Institute (JBRI) and Jeju Hi-Tech Industry Development Institute (HiDI), Jeju 697-943, Korea.

2Department of Chemistry, Cheju National University, Jeju 690-756, Korea.


Email: cghyun@jejuhidi.or.kr or algae@jejuhidi.or.kr






 Accepted: 26 November 2008  Published: 31 January 2009

Copyright © 2009 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


COX-2 (Cyclooxygenase-2) and iNOS (inducible nitric oxide synthase) are involved in various pathophysiological processes such as inflammation. In a search for inhibitors of COX-2 and iNOS, we found that extracts of Dictyota dichotoma inhibit Nitric oxide (NO) and PGE2 generation in LPS-stimulated RAW 264.7 macrophage cells, as well as levels of iNOS and COX-2 mRNA and protein.D. dichotoma were extracted with 80% EtOH. The extract was then partitioned with hexane, CH2Cl2, EtOAc, BuOH, and water, successively. The results indicate that the CH2Cl2 fraction of D. dichotoma extract is an effective inhibitor of LPS-induced NO and PGE2 production in RAW 264.7 cells. These inhibitory effects of the CH2Cl2 fraction of D. dichotoma were accompanied by decreases in the expression of iNOS and COX-2 proteins and iNOS and COX-2 mRNA in dose-dependent pattern. To test the inhibition effects of D. dichotoma fractions on other cytokines, we also performed RT-PCR on TNF-α, IL-1β, and IL-6 in LPS-stimulated RAW 264.7 macrophage cells. In these assays, the CH2Cl2 fraction ofD. dichotoma also showed decreases in the expression of TNF-α, IL-1β, and IL-6 mRNA. Based on these results, we suggest that D. dichotoma extracts may be considered possible anti-inflammatory candidates for human health.

 

Key words: COX-2, Cytokine, Dictyota dichotoma, inflammation, iNOS (inducible nitric oxide synthase), PGE2.


APA (2009). Anti-inflammatory activity of brown alga Dictyota dichotoma in murine macrophage RAW 264.7 cells. Journal of Medicinal Plants Research, 3(1), 001-008.
Chicago Weon-Jong Yoon, Young Min Ham, Kil-Nam Kim, Soo-Yeung Park, Nam Ho Lee, Chang-Gu Hyun and Wook Jae Lee. "Anti-inflammatory activity of brown alga Dictyota dichotoma in murine macrophage RAW 264.7 cells." Journal of Medicinal Plants Research 3, no. 1 (2009): 001-008.
MLA Weon-Jong Yoon, et al. "Anti-inflammatory activity of brown alga Dictyota dichotoma in murine macrophage RAW 264.7 cells." Journal of Medicinal Plants Research 3.1 (2009): 001-008.
   
DOI
URL http://www.academicjournals.org/journal/JMPR/article-abstract/A3BACEF14571

Subscription Form

(default) 34 queries took 18325 ms
NrQueryErrorAffectedNum. rowsTook (ms)
1SELECT `Setting`.`id`, `Setting`.`key`, `Setting`.`value`, `Setting`.`description`, `Setting`.`created`, `Setting`.`modified` FROM `admin_academic_journals`.`settings` AS `Setting` WHERE 1 = 1660
2SELECT `Journal`.`id`, `Journal`.`journal_category_id`, `Journal`.`name`, `Journal`.`issn`, `Journal`.`abbrev`, `Journal`.`pub_abbrev`, `Journal`.`banner`, `Journal`.`colour`, `Journal`.`email`, `Journal`.`password`, `Journal`.`instruction_for_author_file`, `Journal`.`reviewers_guide_file`, `Journal`.`about_text`, `Journal`.`submit_manuscript`, `Journal`.`instructions_for_authors`, `Journal`.`pub_ethics`, `Journal`.`abstracting`, `Journal`.`call_for_papers`, `Journal`.`faculty_1000`, `Journal`.`editors`, `Journal`.`journal_issue_count`, `Journal`.`journ_handling_fee`, `Journal`.`founding_editor`, `Journal`.`founding_editor_address`, `Journal`.`created`, `Journal`.`modified`, `Journal`.`subdomain`, `JournalCategory`.`id`, `JournalCategory`.`name`, `JournalCategory`.`journal_count`, `JournalCategory`.`description`, `JournalCategory`.`created`, `JournalCategory`.`modified` FROM `admin_academic_journals`.`journals` AS `Journal` LEFT JOIN `admin_academic_journals`.`journal_categories` AS `JournalCategory` ON (`Journal`.`journal_category_id` = `JournalCategory`.`id`) WHERE `Journal`.`abbrev` = 'JMPR' LIMIT 1110
3SELECT `JournalIssue`.`id`, `JournalIssue`.`journal_id`, `JournalIssue`.`archive_id`, `JournalIssue`.`volume_number`, `JournalIssue`.`issue_number`, `JournalIssue`.`page_range`, `JournalIssue`.`edition`, `JournalIssue`.`month`, `JournalIssue`.`picture`, `JournalIssue`.`home_issue`, `JournalIssue`.`current_issue`, `JournalIssue`.`articles_count`, `JournalIssue`.`e-book`, `JournalIssue`.`issuu_embed`, `JournalIssue`.`subject`, `JournalIssue`.`created`, `JournalIssue`.`modified` FROM `admin_academic_journals`.`journal_issues` AS `JournalIssue` WHERE `JournalIssue`.`journal_id` = (7)3623620
4SELECT `JournalStat`.`id`, `JournalStat`.`journal_id`, `JournalStat`.`name`, `JournalStat`.`value`, `JournalStat`.`ref_link`, `JournalStat`.`description`, `JournalStat`.`created`, `JournalStat`.`modified` FROM `admin_academic_journals`.`journal_stats` AS `JournalStat` WHERE `JournalStat`.`journal_id` = (7)110
5SELECT `JournalSection`.`id`, `JournalSection`.`name`, `JournalSection`.`journal_id`, `JournalSection`.`description`, `JournalSection`.`created`, `JournalSection`.`modified` FROM `admin_academic_journals`.`journal_sections` AS `JournalSection` WHERE `JournalSection`.`journal_id` = (7)110
6SELECT `JournalStat`.`id`, `JournalStat`.`journal_id`, `JournalStat`.`name`, `JournalStat`.`value`, `JournalStat`.`ref_link`, `JournalStat`.`description`, `JournalStat`.`created`, `JournalStat`.`modified` FROM `admin_academic_journals`.`journal_stats` AS `JournalStat` WHERE `JournalStat`.`journal_id` = 7 AND `JournalStat`.`value` <> ''110
7SELECT `JournalIssue`.`id`, `JournalIssue`.`journal_id`, `JournalIssue`.`archive_id`, `JournalIssue`.`volume_number`, `JournalIssue`.`issue_number`, `JournalIssue`.`page_range`, `JournalIssue`.`edition`, `JournalIssue`.`month`, `JournalIssue`.`picture`, `JournalIssue`.`home_issue`, `JournalIssue`.`current_issue`, `JournalIssue`.`articles_count`, `JournalIssue`.`e-book`, `JournalIssue`.`issuu_embed`, `JournalIssue`.`subject`, `JournalIssue`.`created`, `JournalIssue`.`modified`, `Journal`.`id`, `Journal`.`journal_category_id`, `Journal`.`name`, `Journal`.`issn`, `Journal`.`abbrev`, `Journal`.`pub_abbrev`, `Journal`.`banner`, `Journal`.`colour`, `Journal`.`email`, `Journal`.`password`, `Journal`.`instruction_for_author_file`, `Journal`.`reviewers_guide_file`, `Journal`.`about_text`, `Journal`.`submit_manuscript`, `Journal`.`instructions_for_authors`, `Journal`.`pub_ethics`, `Journal`.`abstracting`, `Journal`.`call_for_papers`, `Journal`.`faculty_1000`, `Journal`.`editors`, `Journal`.`journal_issue_count`, `Journal`.`journ_handling_fee`, `Journal`.`founding_editor`, `Journal`.`founding_editor_address`, `Journal`.`created`, `Journal`.`modified`, `Journal`.`subdomain`, `Archive`.`id`, `Archive`.`month`, `Archive`.`year`, `Archive`.`created`, `Archive`.`modified` FROM `admin_academic_journals`.`journal_issues` AS `JournalIssue` LEFT JOIN `admin_academic_journals`.`journals` AS `Journal` ON (`JournalIssue`.`journal_id` = `Journal`.`id`) LEFT JOIN `admin_academic_journals`.`archives` AS `Archive` ON (`JournalIssue`.`archive_id` = `Archive`.`id`) WHERE `JournalIssue`.`journal_id` = 7 AND `JournalIssue`.`current_issue` = '1' ORDER BY `JournalIssue`.`created` DESC, `JournalIssue`.`month` DESC LIMIT 1110
8SELECT `Article`.`id`, `Article`.`journal_section_id`, `Article`.`journal_issue_id`, `Article`.`article_number`, `Article`.`article_type`, `Article`.`title`, `Article`.`accepted_date`, `Article`.`received_date`, `Article`.`abstract`, `Article`.`abbrev`, `Article`.`full_text`, `Article`.`pages`, `Article`.`doi`, `Article`.`authors_for_citation`, `Article`.`authors`, `Article`.`email`, `Article`.`phone`, `Article`.`address`, `Article`.`has_full_text`, `Article`.`has_reference`, `Article`.`pdf_file`, `Article`.`published`, `Article`.`published_date`, `Article`.`status`, `Article`.`author_id`, `Article`.`created`, `Article`.`modified`, `Article`.`read_count`, `Article`.`shared_count`, `Article`.`download_count`, `Article`.`other_links`, `Article`.`references` FROM `admin_academic_journals`.`articles` AS `Article` WHERE `Article`.`journal_issue_id` = (9113)110
9SELECT COUNT(*) AS `count` FROM `admin_academic_journals`.`articles` AS `Article` LEFT JOIN `admin_academic_journals`.`journal_issues` AS `JournalIssue` ON (`Article`.`journal_issue_id` = `JournalIssue`.`id`) LEFT JOIN `admin_academic_journals`.`journal_sections` AS `JournalSection` ON (`Article`.`journal_section_id` = `JournalSection`.`id`) LEFT JOIN `admin_academic_journals`.`authors` AS `Author` ON (`Article`.`author_id` = `Author`.`id`) WHERE `JournalIssue`.`journal_id` =7 AND `Article`.`published` = 1110
10SELECT `Article`.`id`, `Article`.`journal_section_id`, `Article`.`journal_issue_id`, `Article`.`article_number`, `Article`.`article_type`, `Article`.`title`, `Article`.`accepted_date`, `Article`.`received_date`, `Article`.`abstract`, `Article`.`abbrev`, `Article`.`full_text`, `Article`.`pages`, `Article`.`doi`, `Article`.`authors_for_citation`, `Article`.`authors`, `Article`.`email`, `Article`.`phone`, `Article`.`address`, `Article`.`has_full_text`, `Article`.`has_reference`, `Article`.`pdf_file`, `Article`.`published`, `Article`.`published_date`, `Article`.`status`, `Article`.`author_id`, `Article`.`created`, `Article`.`modified`, `Article`.`read_count`, `Article`.`shared_count`, `Article`.`download_count`, `Article`.`other_links`, `Article`.`references`, `JournalIssue`.`id`, `JournalIssue`.`journal_id`, `JournalIssue`.`archive_id`, `JournalIssue`.`volume_number`, `JournalIssue`.`issue_number`, `JournalIssue`.`page_range`, `JournalIssue`.`edition`, `JournalIssue`.`month`, `JournalIssue`.`picture`, `JournalIssue`.`home_issue`, `JournalIssue`.`current_issue`, `JournalIssue`.`articles_count`, `JournalIssue`.`e-book`, `JournalIssue`.`issuu_embed`, `JournalIssue`.`subject`, `JournalIssue`.`created`, `JournalIssue`.`modified`, `JournalSection`.`id`, `JournalSection`.`name`, `JournalSection`.`journal_id`, `JournalSection`.`description`, `JournalSection`.`created`, `JournalSection`.`modified`, `Author`.`id`, `Author`.`surname`, `Author`.`other_names`, `Author`.`email`, `Author`.`phone`, `Author`.`sex`, `Author`.`institution`, `Author`.`address`, `Author`.`specialization`, `Author`.`country`, `Author`.`password`, `Author`.`last_login`, `Author`.`created`, `Author`.`title`, `Author`.`affiliation`, `Author`.`blacklist_id` FROM `admin_academic_journals`.`articles` AS `Article` LEFT JOIN `admin_academic_journals`.`journal_issues` AS `JournalIssue` ON (`Article`.`journal_issue_id` = `JournalIssue`.`id`) LEFT JOIN `admin_academic_journals`.`journal_sections` AS `JournalSection` ON (`Article`.`journal_section_id` = `JournalSection`.`id`) LEFT JOIN `admin_academic_journals`.`authors` AS `Author` ON (`Article`.`author_id` = `Author`.`id`) WHERE `Article`.`article_number` = 'A3BACEF14571' LIMIT 11119
11SELECT `AbstractTranslation`.`id`, `AbstractTranslation`.`article_id`, `AbstractTranslation`.`language`, `AbstractTranslation`.`abstract`, `AbstractTranslation`.`published`, `AbstractTranslation`.`created`, `AbstractTranslation`.`modified` FROM `admin_academic_journals`.`abstract_translations` AS `AbstractTranslation` WHERE `AbstractTranslation`.`article_id` = (1009904601)000
12SELECT `ArticleTranslation`.`id`, `ArticleTranslation`.`article_id`, `ArticleTranslation`.`name`, `ArticleTranslation`.`url`, `ArticleTranslation`.`translator`, `ArticleTranslation`.`translator_url`, `ArticleTranslation`.`created`, `ArticleTranslation`.`modified` FROM `admin_academic_journals`.`article_translations` AS `ArticleTranslation` WHERE `ArticleTranslation`.`article_id` = (1009904601)000
13SELECT `ArticleAuthor`.`id`, `ArticleAuthor`.`name`, `ArticleAuthor`.`article_id`, `ArticleAuthor`.`email`, `ArticleAuthor`.`phone`, `ArticleAuthor`.`department`, `ArticleAuthor`.`affiliation`, `ArticleAuthor`.`country`, `ArticleAuthor`.`created`, `ArticleAuthor`.`modified` FROM `admin_academic_journals`.`article_authors` AS `ArticleAuthor` WHERE `ArticleAuthor`.`article_id` = (1009904601)000
14SELECT `ArticleReference`.`id`, `ArticleReference`.`title`, `ArticleReference`.`article_id`, `ArticleReference`.`authors`, `ArticleReference`.`year`, `ArticleReference`.`volume`, `ArticleReference`.`pages`, `ArticleReference`.`journal_title`, `ArticleReference`.`google_scholar`, `ArticleReference`.`pub_med`, `ArticleReference`.`url`, `ArticleReference`.`created`, `ArticleReference`.`modified` FROM `admin_academic_journals`.`article_references` AS `ArticleReference` WHERE `ArticleReference`.`article_id` = (1009904601)000
15SELECT `JournalIssue`.`id`, `JournalIssue`.`journal_id`, `JournalIssue`.`archive_id`, `JournalIssue`.`volume_number`, `JournalIssue`.`issue_number`, `JournalIssue`.`page_range`, `JournalIssue`.`edition`, `JournalIssue`.`month`, `JournalIssue`.`picture`, `JournalIssue`.`home_issue`, `JournalIssue`.`current_issue`, `JournalIssue`.`articles_count`, `JournalIssue`.`e-book`, `JournalIssue`.`issuu_embed`, `JournalIssue`.`subject`, `JournalIssue`.`created`, `JournalIssue`.`modified`, `Journal`.`id`, `Journal`.`journal_category_id`, `Journal`.`name`, `Journal`.`issn`, `Journal`.`abbrev`, `Journal`.`pub_abbrev`, `Journal`.`banner`, `Journal`.`colour`, `Journal`.`email`, `Journal`.`password`, `Journal`.`instruction_for_author_file`, `Journal`.`reviewers_guide_file`, `Journal`.`about_text`, `Journal`.`submit_manuscript`, `Journal`.`instructions_for_authors`, `Journal`.`pub_ethics`, `Journal`.`abstracting`, `Journal`.`call_for_papers`, `Journal`.`faculty_1000`, `Journal`.`editors`, `Journal`.`journal_issue_count`, `Journal`.`journ_handling_fee`, `Journal`.`founding_editor`, `Journal`.`founding_editor_address`, `Journal`.`created`, `Journal`.`modified`, `Journal`.`subdomain`, `Archive`.`id`, `Archive`.`month`, `Archive`.`year`, `Archive`.`created`, `Archive`.`modified` FROM `admin_academic_journals`.`journal_issues` AS `JournalIssue` LEFT JOIN `admin_academic_journals`.`journals` AS `Journal` ON (`JournalIssue`.`journal_id` = `Journal`.`id`) LEFT JOIN `admin_academic_journals`.`archives` AS `Archive` ON (`JournalIssue`.`archive_id` = `Archive`.`id`) WHERE `JournalIssue`.`id` = 3340 LIMIT 1110
16SELECT `Article`.`id`, `Article`.`journal_section_id`, `Article`.`journal_issue_id`, `Article`.`article_number`, `Article`.`article_type`, `Article`.`title`, `Article`.`accepted_date`, `Article`.`received_date`, `Article`.`abstract`, `Article`.`abbrev`, `Article`.`full_text`, `Article`.`pages`, `Article`.`doi`, `Article`.`authors_for_citation`, `Article`.`authors`, `Article`.`email`, `Article`.`phone`, `Article`.`address`, `Article`.`has_full_text`, `Article`.`has_reference`, `Article`.`pdf_file`, `Article`.`published`, `Article`.`published_date`, `Article`.`status`, `Article`.`author_id`, `Article`.`created`, `Article`.`modified`, `Article`.`read_count`, `Article`.`shared_count`, `Article`.`download_count`, `Article`.`other_links`, `Article`.`references` FROM `admin_academic_journals`.`articles` AS `Article` WHERE `Article`.`journal_issue_id` = (3340)880
17SELECT `ArticleMetric`.`id`, `ArticleMetric`.`article_id`, `ArticleMetric`.`ip`, `ArticleMetric`.`read_t`, `ArticleMetric`.`count`, `ArticleMetric`.`country`, `ArticleMetric`.`region`, `ArticleMetric`.`continent`, `ArticleMetric`.`created`, `ArticleMetric`.`modified` FROM `admin_academic_journals`.`article_metrics` AS `ArticleMetric` WHERE `ArticleMetric`.`article_id` = 1009904601 AND `ArticleMetric`.`read_t` = 'article-abstract' AND `ArticleMetric`.`ip` = '54.225.39.142' AND DATE_FORMAT(`ArticleMetric`.`created`, '%Y-%m-%d') = '2017-09-20' LIMIT 1005647
18BEGIN005647
19INSERT INTO `admin_academic_journals`.`article_metrics` (`read_t`, `count`, `article_id`, `ip`, `country`, `region`, `continent`, `modified`, `created`) VALUES ('article-abstract', 1, 1009904601, '54.225.39.142', 'United States', 'Virginia', 'North America', '2017-09-20 05:18:16', '2017-09-20 05:18:16')113491
20COMMIT113491
21SELECT `Setting`.`id`, `Setting`.`key`, `Setting`.`value`, `Setting`.`description`, `Setting`.`created`, `Setting`.`modified` FROM `admin_academic_journals`.`settings` AS `Setting` WHERE 1 = 1664
22SELECT `Setting`.`id`, `Setting`.`key`, `Setting`.`value`, `Setting`.`description`, `Setting`.`created`, `Setting`.`modified` FROM `admin_academic_journals`.`settings` AS `Setting` WHERE 1 = 1660
23SELECT `Setting`.`id`, `Setting`.`key`, `Setting`.`value`, `Setting`.`description`, `Setting`.`created`, `Setting`.`modified` FROM `admin_academic_journals`.`settings` AS `Setting` WHERE 1 = 1660
24SELECT `JournalIssue`.`id`, `JournalIssue`.`journal_id`, `JournalIssue`.`archive_id`, `JournalIssue`.`volume_number`, `JournalIssue`.`issue_number`, `JournalIssue`.`page_range`, `JournalIssue`.`edition`, `JournalIssue`.`month`, `JournalIssue`.`picture`, `JournalIssue`.`home_issue`, `JournalIssue`.`current_issue`, `JournalIssue`.`articles_count`, `JournalIssue`.`e-book`, `JournalIssue`.`issuu_embed`, `JournalIssue`.`subject`, `JournalIssue`.`created`, `JournalIssue`.`modified` FROM `admin_academic_journals`.`journal_issues` AS `JournalIssue` WHERE `JournalIssue`.`id` = 3340 LIMIT 1112
25SELECT `Setting`.`id`, `Setting`.`key`, `Setting`.`value`, `Setting`.`description`, `Setting`.`created`, `Setting`.`modified` FROM `admin_academic_journals`.`settings` AS `Setting` WHERE 1 = 1660
26SELECT `JournalIssue`.`id`, `JournalIssue`.`journal_id`, `JournalIssue`.`archive_id`, `JournalIssue`.`volume_number`, `JournalIssue`.`issue_number`, `JournalIssue`.`page_range`, `JournalIssue`.`edition`, `JournalIssue`.`month`, `JournalIssue`.`picture`, `JournalIssue`.`home_issue`, `JournalIssue`.`current_issue`, `JournalIssue`.`articles_count`, `JournalIssue`.`e-book`, `JournalIssue`.`issuu_embed`, `JournalIssue`.`subject`, `JournalIssue`.`created`, `JournalIssue`.`modified` FROM `admin_academic_journals`.`journal_issues` AS `JournalIssue` WHERE `JournalIssue`.`id` = 3340 LIMIT 1112
27SELECT `Setting`.`id`, `Setting`.`key`, `Setting`.`value`, `Setting`.`description`, `Setting`.`created`, `Setting`.`modified` FROM `admin_academic_journals`.`settings` AS `Setting` WHERE 1 = 1664
28SELECT `Setting`.`id`, `Setting`.`key`, `Setting`.`value`, `Setting`.`description`, `Setting`.`created`, `Setting`.`modified` FROM `admin_academic_journals`.`settings` AS `Setting` WHERE 1 = 1664
29SELECT `Setting`.`id`, `Setting`.`key`, `Setting`.`value`, `Setting`.`description`, `Setting`.`created`, `Setting`.`modified` FROM `admin_academic_journals`.`settings` AS `Setting` WHERE 1 = 1664
30SELECT `Setting`.`id`, `Setting`.`key`, `Setting`.`value`, `Setting`.`description`, `Setting`.`created`, `Setting`.`modified` FROM `admin_academic_journals`.`settings` AS `Setting` WHERE 1 = 1664
31SELECT `Setting`.`id`, `Setting`.`key`, `Setting`.`value`, `Setting`.`description`, `Setting`.`created`, `Setting`.`modified` FROM `admin_academic_journals`.`settings` AS `Setting` WHERE 1 = 1660
32SELECT `Logo`.`id`, `Logo`.`name`, `Logo`.`banner`, `Logo`.`description`, `Logo`.`created`, `Logo`.`modified` FROM `admin_academic_journals`.`logos` AS `Logo` WHERE `Logo`.`id` = 1 LIMIT 1112
33SELECT `Setting`.`id`, `Setting`.`key`, `Setting`.`value`, `Setting`.`description`, `Setting`.`created`, `Setting`.`modified` FROM `admin_academic_journals`.`settings` AS `Setting` WHERE 1 = 1664
34SELECT `Journal`.`id`, `Journal`.`journal_category_id`, `Journal`.`name`, `Journal`.`issn`, `Journal`.`abbrev`, `Journal`.`pub_abbrev`, `Journal`.`banner`, `Journal`.`colour`, `Journal`.`email`, `Journal`.`password`, `Journal`.`instruction_for_author_file`, `Journal`.`reviewers_guide_file`, `Journal`.`about_text`, `Journal`.`submit_manuscript`, `Journal`.`instructions_for_authors`, `Journal`.`pub_ethics`, `Journal`.`abstracting`, `Journal`.`call_for_papers`, `Journal`.`faculty_1000`, `Journal`.`editors`, `Journal`.`journal_issue_count`, `Journal`.`journ_handling_fee`, `Journal`.`founding_editor`, `Journal`.`founding_editor_address`, `Journal`.`created`, `Journal`.`modified`, `Journal`.`subdomain` FROM `admin_academic_journals`.`journals` AS `Journal` WHERE `Journal`.`id` = 7 LIMIT 1110