Journal of Medicinal Plants Research
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Article Number - 9F32DD724927


Vol.7(20), pp. 1494-1505 , May 2013
https://doi.org/10.5897/JMPR12.1116
ISSN: 1996-0875


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Full Length Research Paper

Hepatoprotective effect of dandelion (Taraxacum officinale) against induced chronic liver cirrhosis


Abdulrahman L. Al-Malki1, Mohamed Kamel Abo-Golayel1,2*, Gamal Abo-Elnaga3 and

Hassan Al-Beshri4




1Biochemistry Department, Faculty of Science, King Abdulaziz University, Saudi Arabia.

2Medical Research Center, Ain Shams University Hospitals, Ain Shams University, Egypt.

3Pathology Department, Faculty of Medicine, Ain Shams University, Egypt.

4Chemistry Department, Faculty of Science, King Abdulaziz University, Saudi Arabia.


Email: [email protected]






 Accepted: 19 April 2013  Published: 25 May 2013

Copyright © 2013 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Recently, it was found that dandelion flower extract may fight free radicals (chemical by-products known to damage DNA). Health care providers clinically use dandelion root to promote liver detoxification. Dandelion leaves water extract was investigated for hepatoprotective activity against carbon tetrachloride induced liver damage. The aim of the study was to evaluate the efficacy of the hepatoprotective activity of dandelion leaves water extract against carbon tetrachloride (CCl4) intoxication in liver albino rats. Carbon tetrachloride was used as hepatotoxic agent and dandelion leaves water extract was used as a probable hepato-protective agent. Various biochemical parameters were studied to evaluate the hepatoprotective activity of dandelion leaves water extract. The study was also supported by histopathology of liver sections and DNA extraction of the studied animals to investigate the genomic DNA integrity. The results revealed that the serum markers in rats treated with CCl4 recorded elevated concentration, indicating severe hepatic damage by CCl4, while the blood samples from dandelion treated animals showed significant reduction in the serum markers, indicating the effect of the plant extract in restoring the normal functional ability of the hepatocytes. The present study revealed that dandelion leaf water extract could afford a significant protection against CCl4 induced hepatocellular injury.

 

Key words: Taraxacum officinale, dandelion leaf water extract (DLWE), hepatoprotective activity, carbon tetrachloride (CCl4) damage.


APA (2013). Hepatoprotective effect of dandelion (Taraxacum officinale) against induced chronic liver cirrhosis. Journal of Medicinal Plants Research, 7(20), 1494-1505.
Chicago Abdulrahman L. Al-Malki, Mohamed Kamel Abo-Golayel, Gamal Abo-Elnaga and Hassan Al-Beshri. "Hepatoprotective effect of dandelion (Taraxacum officinale) against induced chronic liver cirrhosis." Journal of Medicinal Plants Research 7, no. 20 (2013): 1494-1505.
MLA Abdulrahman L. Al-Malki, et al. "Hepatoprotective effect of dandelion (Taraxacum officinale) against induced chronic liver cirrhosis." Journal of Medicinal Plants Research 7.20 (2013): 1494-1505.
   
DOI https://doi.org/10.5897/JMPR12.1116
URL http://www.academicjournals.org/journal/JMPR/article-abstract/9F32DD724927

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