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Article Number - 7AB577614625


Vol.3(1), pp. 024-030 , January 2009

ISSN: 1996-0875



Full Length Research Paper

Phenolics from Spirulina maxima: Over-production and in vitro protective effect of its phenolics on CCl4 induced hepatotoxicity


Hanaa H. Abd El-Baky1*, Farouk K. El Bazand Gamal S. El-Baroty2




1Plant Biochemistry Department, National Research Centre, Dokki, Cairo, Egypt.

Department of Biochemistry, Faculty of Agriculture, Cairo University, Egypt.


Email: abdelbakyh@hotmail.com






 Accepted: 04 November 2008  Published: 31 January 2009

Copyright © 2009 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


This study illustrates the process of enhancing phenolics synthesis in Spirulinamaxima grown in Zarrouk’s medium supplemented with sodium nitrate (NaNO3) and/or phenylalanine (L-PA); attaining highest production were obtained in medium containing 3.77 gL-1 NaNO3 and 100 mgL-1 L-PA. HPLC profile showed the pre-sence of phenolic acids and flavonoids predominantly with gallate, chlorogenate, cinnamate, pinostrobate and p-OH-benzoates. The protective action of Spirulinaphenolic compounds (SPC) against CCl4-induced in vitro, hepato-toxicity symptoms like microsomal lipid peroxidation and hydroxyl radical formation were studied. SPC exhibited antioxidant effects on DPPH radical scavenging with IC50values ranging from 23.22 to 35.62 µg.mL-1 and inhibited CCl4-induced lipid peroxidation in hepato-microsoms model, in dose-depended manner. Their protective potential was comparable to that of standard phenolic antioxidants such as BHT, BHA and α–tocopherol (IC50 values ranged from 13.22 to 23.62 µg.mL-1).

 

Key wordsSpirulina maxima, antioxidant activity, carbon tetrachloride, hepato-protective effects.


APA (2009). Phenolics from Spirulina maxima: Over-production and in vitro protective effect of its phenolics on CCl4 induced hepatotoxicity. Journal of Medicinal Plants Research, 3(1), 024-030.
Chicago Hanaa H. Abd El-Baky, Farouk K. El Baz and Gamal S. El-Baroty. "Phenolics from Spirulina maxima: Over-production and in vitro protective effect of its phenolics on CCl4 induced hepatotoxicity." Journal of Medicinal Plants Research 3, no. 1 (2009): 024-030.
MLA Hanaa H. Abd El-Baky, Farouk K. El Baz and Gamal S. El-Baroty. "Phenolics from Spirulina maxima: Over-production and in vitro protective effect of its phenolics on CCl4 induced hepatotoxicity." Journal of Medicinal Plants Research 3.1 (2009): 024-030.
   
DOI
URL http://www.academicjournals.org/journal/JMPR/article-abstract/7AB577614625

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