Abstract

This study evaluate the effects of sage hydroalcoholic extract (SE) and sage essential oil (SO) on the inflammatory response using an experimental model of acute inflammation and a leukocyte migration assay. In the carrageenan-induced pleurisy test, SE did not reduce the exudate volume and leukocyte migration to the pleura, but SE exerted a topical anti-inflammatory effect by significantly inhibiting croton oil-induced ear edema. All SO doses tested significantly inhibited leukocyte chemotaxis induced by casein and reduced the number of rolling, adhesion, and leukocytes migration to spermatic fascia after inflammatory stimulus. Our data demonstrated that SO has anti-inflammatory activity.

Key words: Salvia officinalis, essential oil, anti-inflammatory, medicinal plants.