Vol.6(35), pp. 4934-4939 , September 2012
DOI: 10.5897/JMPR12.251 Total Views: 208
ISSN: 1996-0875 Downloaded: 109
Full Length Research Paper
Gessilda Alcantara Nogueira de Melo1*, Jefferson Pitelli Fonseca1, Thiago Oliveira Farinha1, Rilson José do Pinho1, Márcio José Damião1, Renata Grespan1, Expedito Leite da Silva2, Ciomar A. Bersani-Amado1 and Roberto Kenji Nakamura Cuman1
1Department of Pharmacology and Therapeutics, State University of Maringá, CEP 87020-900 Maringá – PR, Brazil.
2Department of Chemistry, State University of Maringá, Maringá – PR, Brazil.
Accepted: 22 March 2012 Published: 12 September 2012
Copyright © 2012 Author(s) retain the copyright of this article.
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This study evaluate the effects of sage hydroalcoholic extract (SE) and sage essential oil (SO) on the inflammatory response using an experimental model of acute inflammation and a leukocyte migration assay. In the carrageenan-induced pleurisy test, SE did not reduce the exudate volume and leukocyte migration to the pleura, but SE exerted a topical anti-inflammatory effect by significantly inhibiting croton oil-induced ear edema. All SO doses tested significantly inhibited leukocyte chemotaxis induced by casein and reduced the number of rolling, adhesion, and leukocytes migration to spermatic fascia after inflammatory stimulus. Our data demonstrated that SO has anti-inflammatory activity.
Key words: Salvia officinalis, essential oil, anti-inflammatory, medicinal plants.