Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3553

Full Length Research Paper

Effect of aqueous leaf extracts of Leptadenia hastata Pers (Decne) on spermiogram and testicular histology in albino rats (Wistar strain)

Victoria Adam Maina
  • Victoria Adam Maina
  • Department of Theriogenology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria.
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Innocent Damudu Peter
  • Innocent Damudu Peter
  • Department of Theriogenology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria.
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Dauda Yahi
  • Dauda Yahi
  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria.
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Umar Kyari Sandabe
  • Umar Kyari Sandabe
  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria.
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Godwin Onyeamaechi Egwu
  • Godwin Onyeamaechi Egwu
  • Department of Veterinary Medicine, Faculty of Veterinary Medicine University of Maiduguri, Maiduguri, Nigeria.
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  •  Received: 12 February 2018
  •  Accepted: 09 April 2018
  •  Published: 11 April 2018

Abstract

This study was designed to determine the effects of prolonged oral administration of aqueous leaf extract of Leptadenia hastata Pers (Decne) on sperm concentration, sperm motility and testicular histology in Wistar rats.  Rats were given graded doses (200, 400, 600 and 800 mg kg-1) of aqueous leaf extract of L. hastata orally for 28 days. Weekly changes in sperm concentration and motility as well as testicular weight and histology were monitored. Sperm concentration, motility and testicular weights did not show significant change (p>0.05) among the groups, but a significant difference (p<0.05) exist between control group and the group that had the highest dose (800 mg/kg) of L. hastata. Histopathological studies revealed marked depletion of spermatozoa in the testes and epididymis of rats that received 800 mg/kg of L. hastata. Prolonged administration of aqueous leaf extract of L. hastata at 800 mg/kg caused a reduction in total sperm concentration, sperm motility and a reduction in testicular weight in rats.

Key words: Fertility, Leptadenia hastata, spermiogram, rats, testis.