Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3540

Full Length Research Paper

Pharmaceutical topical gel containing proanthocyanidin polymers-rich fraction from Stryphnodendron adstringens

Marco Antonio Costa
  • Marco Antonio Costa
  • Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá, PR, Brazil.
  • Google Scholar
Andressa Blainski
  • Andressa Blainski
  • Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá, PR, Brazil.
  • Google Scholar
Vanessa Kaplum
  • Vanessa Kaplum
  • Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá, PR, Brazil.
  • Google Scholar
Marli Miriam de Souza Lima
  • Marli Miriam de Souza Lima
  • Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá, PR, Brazil.
  • Google Scholar
Tania Ueda-Nakamura
  • Tania Ueda-Nakamura
  • Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá, PR, Brazil.
  • Google Scholar
Benedito Prado Dias Filho
  • Benedito Prado Dias Filho
  • Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá, PR, Brazil.
  • Google Scholar
Joao Carlos Palazzo de Mello
  • Joao Carlos Palazzo de Mello
  • Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá, PR, Brazil.
  • Google Scholar
Celso Vataru Nakamura
  • Celso Vataru Nakamura
  • Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Maringá, PR, Brazil.
  • Google Scholar


  •  Received: 19 December 2017
  •  Accepted: 22 March 2018
  •  Published: 24 March 2018

Abstract

The stem bark of Stryphnodendron adstringens, popularly known in Brazil as "barbatimão", has many biological activities, including antifungal activity. Considering the increasing interest of using "barbatimão" extract in the treatment of vaginal candidiasis, the aim of this study was to propose a pharmaceutical topical gel containing a proanthocyanidin polymers-rich fraction for use as a pharmacological agent in vaginal gels, as well as to evaluate the validation parameters for the determination of phenolic compounds. UV/Vis spectrophotometry was used as a quantitative method for quality control of topical gel and a proanthocyanidin polymers-rich fraction was used in this work. The proposed gel seems suitable for use in vaginal infections, and the analytical method was linear, specific, precise, accurate, reproducible and robust. This methodology complies with analytical application demands and it is easily performed in work routine.

Key words: Barbatimão, polyphenols, Stryphnodendron adstringens, UV/Vis spectrophotometry, vaginal gel, validation method.