Journal of
Medicinal Plants Research

  • Abbreviation: J. Med. Plants Res.
  • Language: English
  • ISSN: 1996-0875
  • DOI: 10.5897/JMPR
  • Start Year: 2007
  • Published Articles: 3830

Full Length Research Paper

The effect of quince leaf decoction on renal injury induced by hypercholesterolemia in rabbits: A pilot study

Abolghasem Jouyban1, Mohammadali M. Shoja2*, Mohammad Reza Ardalan3, Maryam Khoubnasabjafari4, Alireza Sadighi2, R. Shane Tubbs5, Paul S. Agutter6 and Kamyar Ghabili2
1Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 2Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 3Department of Nephrology, Dialysis and Transplantation, Tabriz University of Medical Sciences, Tabriz, Iran. 4Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. 5Section of Pediatric Neurosurgery, Children’s Hospital, Birmingham, AL, USA. 6Theoretical Medicine and Biology Group, Glossop, Derbyshire, UK.
Email: [email protected]

  •  Accepted: 04 November 2010
  •  Published: 09 October 2011

Abstract

There has been no investigation on the efficacy of quince extracts (Cydonia oblonga Miller) against hyperlipidemia-induced renal injury. In the present study, this hypothesis was evaluated by a histological comparison of kidney tissues from New Zealand white rabbits fed on a cholesterol-rich diet with and without a quince leaf extract supplement. Mild glomerular injury and moderate tubular damage were apparent in all rabbits in disease group. Meanwhile, milder tubular injury was detected in all animals in treatment group. The results were consistent with the hypothesis and suggest that a more extended study would be justified.

 

Key words: Quince, kidney, cholesterol, herb, diet.