March 2015

Evaluation of BNC2 as a new candidate gene for hypospadias

In order to evaluate the use of the BNC2 gene in clinical practice regarding hypospadias, the presence of the impact of mutations in BNC2 gene in males who had been treated surgically for hypospadias in Sweden (N=413) and controls (N=455) were evaluated. Mutational screening was performed using Sanger sequencing and genotyping by Taqman allelic discrimination, and the findings were evaluated by disease-causing potential...

Author(s): Anna Skarin Nordenvall, Jia Cao, Ellen Markljung, Izabella Baranowska Körberg and Agneta Nordenskjöld,