Abstract

In order to test the role of platelet activation in the talar osteochondral disease, the mean platelet volume (MPV) in patients undergoing treatment of talar osteochondral disease was evaluated. White blood cell count and highly sensitive C-reactive protein were evaluated in 50 patients with osteochondral defect of talus. Disease activity was assessed according to American Orthopedic Foot and Ankle Society scoring. Additionally, visual analog scale for the pain assessment was used for the study. Biochemical parameters, rehabilitation parameters, and MPV levels were compared with each other at the admission and 3 weeks after surgery. MPV was significantly lower in patients with osteochondral lesions of talus after treatment as compared to admission levels. MPV and C-reactive protein levels decreased together. American orthopedic foot ankle score of the patients were increased after surgery. Visual analog scale decreased suggestive levels. It was proposed that MPV provides a useful marker in activity of inflammatory osteochondral disease. The aim of this study is to define the effect of platelet activation in talar osteochondral disease.

Key words: Talus, osteochondral lesion, platelet volume (MPV), biomarker.