Journal of Bioinformatics and Sequence Analysis
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Article Number - 68FFD6E2450


Vol.1(2), pp. 031-040 , June 2009

ISSN: 2141-2464



Full Length Research Paper

Existence of snoRNA, microRNA, piRNA characteristics in a novel non-coding RNA: x-ncRNA and its biological implication in Homo sapiens


Kandhavelu Meenakshisundaram*, Lammi Carmen, Buccioni Michela, Dal Ben Diego, Volpini Rosaria, Marucci Gabriella




Pharma Biotech lab, Department of Chemical Science, University of Camerino, Via S. Agostino 1, Camerino (MC) - 62032, Italy.


Email: imsk1982@gmail.com






 Accepted: 06 June 2009  Published: 30 June 2009

Copyright © 2009 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


 

Comparative genomic analysis constitutes a powerful approach for the systematic understanding of genome. The comparative and evolutionary analysis of known microRNAs in Homo sapiens elucidates the discovery of the existence of the novel non-coding RNA, which is transcribed from the unique gene precursor and produces three different non coding RNAs such as piRNA, snoRNA and microRNA. This new characteristics RNA is named as x-non coding RNA (x-ncRNA). This characteristic pattern shows evolutionary signatures dictated by its precise selective significance and synteny. The evidence of x-ncRNA processing and functionality from hairpin arms were proven by systematic analysis. x-ncRNA analysis proven the bio genesis of human piRNA is originated from the dsDNA, which is also involved in the synthesis of piRNA and/or microRNA, through dicer. These data also shows the presence of human sno-microRNA. Our data demonstrates that the existence of x-ncRNA, genomic origin, conceivable bio genesis pathway, evolutionary relationship and its functions.

 

Key words: snoRNA, microRNA, piRNA, Biogenesis, novel noncoding RNA (x-ncRNA).


APA (2009). Existence of snoRNA, microRNA, piRNA characteristics in a novel non-coding RNA: x-ncRNA and its biological implication in Homo sapiens. Journal of Bioinformatics and Sequence Analysis, 1(2), 031-040.
Chicago Kandhavelu Meenakshisundaram, Lammi Carmen, Buccioni Michela, Dal Ben Diego, Volpini Rosaria, Marucci Gabriella. "Existence of snoRNA, microRNA, piRNA characteristics in a novel non-coding RNA: x-ncRNA and its biological implication in Homo sapiens." Journal of Bioinformatics and Sequence Analysis 1, no. 2 (2009): 031-040.
MLA K, et al. "Existence of snoRNA, microRNA, piRNA characteristics in a novel non-coding RNA: x-ncRNA and its biological implication in Homo sapiens." Journal of Bioinformatics and Sequence Analysis 1.2 (2009): 031-040.
   
DOI
URL http://www.academicjournals.org/journal/JBSA/article-abstract/68FFD6E2450

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