International Journal of
Nutrition and Metabolism

  • Abbreviation: Int. J. Nutr. Metab.
  • Language: English
  • ISSN: 2141-2332
  • DOI: 10.5897/IJNAM
  • Start Year: 2009
  • Published Articles: 127

Full Length Research Paper

α-Glucosidase inhibitory activities of some Oxovanadium(IV) complexes: Examples of low IC50 values

Sristicheta Misra
  • Sristicheta Misra
  • Department of Chemistry, University of Allahabad, Allahabad-211002, India.
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Krishna Bihari Pandeya
  • Krishna Bihari Pandeya
  • Department of Chemistry, University of Allahabad, Allahabad-211002, India.
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Ashok K. Tiwari
  • Ashok K. Tiwari
  • Division of Pharmacology, Indian Institute of Chemical Technology, Hyderabad-500007, India.
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Amtul Z. Ali
  • Amtul Z. Ali
  • Division of Pharmacology, Indian Institute of Chemical Technology, Hyderabad-500007, India.
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Thimmapatruni Saradamani
  • Thimmapatruni Saradamani
  • Division of Pharmacology, Indian Institute of Chemical Technology, Hyderabad-500007, India.
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Sachin B. Agawane
  • Sachin B. Agawane
  • Division of Pharmacology, Indian Institute of Chemical Technology, Hyderabad-500007, India.
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Kuncha Madhusudana
  • Kuncha Madhusudana
  • Division of Pharmacology, Indian Institute of Chemical Technology, Hyderabad-500007, India.
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  •  Accepted: 25 October 2011
  •  Published: 31 January 2012

Abstract

α-Glucosidase inhibition measurements have been made on oxovanadium(IV) complexes of eight Schiff base ligands. Three of the complexes show exceptionally low IC50 values: VO(sal-anl)2 = 2.105 µM, VO(sal-mxyanl)2 = 1.26 µM and VO(sal-ntranl)2 = 1.26 µM. In-vivo experiments for antihyperglycemic activity carried out on one of these complexes, viz., VO(sal-mxyanl)2, reveal that the complex decreases blood glucose level by ~ 12% .

 

Key words: α-Glucosidase inhibition, oxovanadium (IV) complexes, Schiff bases, antihyperglycemic activity.

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This article is published under the terms of the Creative Commons Attribution License 4.0

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