March 2011
Avoidable childhood death: A case of mismanagement and inappropriate medication use
Rational drug usage, clinical regulations and pharmaceutical care are important features of health practice. Thus; we have aimed case report to elaborate the clinical pharmaceutical services. A 3 year old girl, was presented in a hospital with minor burn that happened by spilt hot water on her wrist. She was in severe pain. The emergency ward staff applied an ointment. The doctor instructed injection Dormicum...
March 2011
Stability-indicating (liquid chromatographic) LC method for the determination of rifabutin in bulk drug and in pharmaceutical dosage form
A novel stability-indicating LC assay method was developed and validated for quantitative determination of Rifabutin in bulk drugs and in pharmaceutical dosage form in the presence of degradation products generated from forced degradation studies. An isocratic, reversed phase LC method was developed to separate the drug from the degradation products, using an Ace5-C18 (250 x 4.6 mm, 5 µm) column, and 50 mM...
March 2011
Immunomodulatory activity of various extracts of Adhatoda vasica Linn. in experimental rats
Methanolic, chloroform and diethyl ether extracts of leaves of Indian medicinal plantAdhatoda vasica Linn. were pharmacologically validated for its immunomodulatory properties in experimental animals. Oral administration of extracts at a dose of 400 mg/kg in adult male Wister rats significantly increased the percentage neutrophil adhesion to nylon fibers (P<0.001). It extracts were also found to induce...
March 2011
Sex based pharmacological treatment in patients with metabolic syndrome: Findings from the Isfahan healthy heart program
Pharmacological therapy is a critical step in the management of individuals with the metabolic syndrome (MetS) when lifestyle modifications cannot achieve the therapeutic goals. However, it has been well-documented that there is no single best therapy other than weight loss, and that treatment should be targeted at individual components of the MetS. The objective of this study was to investigate the treatment of...
March 2011
Cytotoxic evaluation of fluvastatin and rosuvastatin and effect of fluvastatin in the hela cell cycle
3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, were originally designed to reduce cholesterol biosynthesis and have been extensively used as prevention drugs against hyperlipidemia and cardiovascular conditions. Recently, these compounds have been shown to display chemopreventive activity against cancer. However, the effects of statins on cancer are not completely understood. For this reason, we...
March 2011
Element content analysis of plants of genus Ficus using atomic absorption spectrometer
Ficus species have wide distribution and uses worldwide traditionally as medicine, vegetable, food, fodder and fuel wood etc. The flame atomic absorption spectrophotometer was employed for the estimation, conducted on four plant parts (leaves, bark, aerial roots and fruits) of 12 samples of eight medicinally important species of Ficus and nine samples of wild edible fruits of genus Ficus, collected...
March 2011
Spica Prunellae extract promotes mitochondrion-dependent apoptosis in human colon carcinoma cell line
Spica Prunellae (Prunella vulgaris fruiting spikes) has long been used as an important component in formulated prescriptions of Chinese traditional medicine to treat various kinds of cancer. However, the precise mechanism of the anti-cancer activity of Spica Prunellae remains to be elucidated. In this report, we investigated the cellular effects of the ethanol extract of Spica Prunellae (EESP) in the...
March 2011
Clinical evaluation of green tea polyphenols in treatment of pharyngitis in human subjects
Tea from Camellia sinensis (L.) Kuntze has long been used in herb medicine and recognized to possess anti-inflammative effects. The aim of the current study was to evaluate the therapeutic effects of green tea polyphenols in treatment of pharyngitis in human subjects. The clinical study was carried out as a randomized, double-blind, parallel-group comparative trial. It was found that the integral scores of all...
March 2011
Resistance to erythromycin of Campylobacter jejuni and Campylobacter coli isolated from animals and humans
The sensititivity of thermophilic Campylobacter strains isolated from caecum of broiler chickens as well as caecum and colon of pigs and human stools, were tested against erythromycin. In 16 strains isolated in broiler chickens, resistance rate was found to be 12.50%. Three of 10 strains of Campylobacter jejuni and one of 6 strains ofCampylobacter coli isolated from broiler chickens...
March 2011
A comparison study of Morven gold and Tander virginia cigarettes with respect to its spasmogenic, spasmolytic and chemical screening
The ethanolic extracts derived from cigarettes (Morven gold and Tander virginia) were screened for chemicals, spasmogenic and spasmolytic activities. M. gold extract showed a strong relaxant activity that is 70% against KCl induced contractions while T. virginiawas found to have a mild spasmolytic activity of (06%). Furthermore, a moderate spasmogenic effect of M. gold had being...
March 2011
Antinociceptive activity of some 1,4-substituted piperidine derivatives using tail flick method in mice
We have examined the potential antinociceptive effects of some piperidine derivatives (6a-f), using tail flick method in mice. Morphine was used as positive control drug. The results showed that compound 6b, having a bromine atom at 4 position, was the most active agent tested. The activity of this compound at 50 mg/kg was comparable to morphine (3 mg/kg). Based on the similarities between our compounds and meperidine...
March 2011
Aconitine mediates connexin43 and PKCα phosphorylation status in cultured ventricular myocytes of neonatal rats
Aconitine, a strong poisonous type of alkaloid, has a pharmaceutical effect in stimulating the membranes of cardiomyocyte. However, other effects of aconitine on the Connexin43 (Cx43) and PKCα expression on cardiomyocyte are unknown. In this study, we investigated whether aconitine also mediates the phosphorylation status of Cx43 and PKCα in cultured ventricular myocytes of neonatal rats. The band...
March 2011
Analgesic activities of ethanolic extract of the root of Carpolobia lutea
The analgesic activities of the aqueous extract of Carpolobia lutea was evaluated in mice and rats using the mouse writhing, tail flick and formalin induced pain tests. Analgesic studies were performed using three models; mouse writhing assay, formalin test and tail flick assay. The extract (1500 to 2500 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant (P<0.05) inhibition of the second...
March 2011
Influence of the aryl substituent identity in 4-arylamino-3-nitrocoumarins on their antimicrobial activity
Two new and six previously known coumarin derivatives with promising biological properties were synthesized in moderate to good yields by reaction of 4-chloro-3-nitro-coumarin and the appropriate arylamine in ethyl acetate in the presence of triethylamine. The synthesized compounds were evaluated for their in vitroantibacterial and antifungal activities against pathogenic strains. A correlation between the aryl...
March 2011
Protective effects of rosiglitazone on the endothelial cells in a rabbit iliac artery balloon injury model
To investigate the protective effects of rosiglitazone on the endothelial cells in a rabbit iliac artery balloon injury, thirty male New Zealand white rabbits were randomly divided into control group (hypercholesterol diet), balloon injury group (hypercholesterol diet plus balloon endothelial denudation) and rosiglitazone group (balloon endothelial denudation plus hypercholesterol diet and rosiglitazone). Rabbits were...
March 2011
Polysaccharides from Portulaca oleracea (purslane) supplementation lowers acute exercise induced oxidative stress in young rats
The present study was designed to determine the effects of polysaccharides from purslane (PFP) supplementation on acute exercise induced oxidative stress in young male Sprague-Dawley rats. Animals were divided randomly into four groups, that is control group (C), low-dose PFP supplemented group (LP), middle-dose PFP supplemented group (MP) and high-dose PFP supplemented group (HP). Each group contains eight animals. The...
March 2011
Survey of career identity and job satisfaction among young hospital pharmacists in Guangdong province, China
The situation of career identity and job satisfaction among young hospital pharmacists in Guangdong, China was investigated. A mail-based questionnaire was sent to young hospital pharmacists in Guangdong, China. The questionnaire was designed to obtain information regarding demographic characteristics, career identity and job satisfaction. Pharmacists who were under 35 years old were defined as young pharmacists. Data...
March 2011
A comparative analysis of two medicinal plants used to treat common skin conditions in South Africa
Infectious dermatological diseases are a common occurrence in southern Africa. Plants showing dermatological properties are highly sought after due to their ability to stop bleeding, speed up wound healing and to soothe skin exposed to burns (Lewis and Elvin-Lewis, 1977). An attempt was made to validate the use of Haworthia limifoliaand Aloe excelsa against microbial properties from extracts of leaves...
March 2011
Extract of Coelatura aegyptiaca, a freshwater clam, ameliorates hepatic oxidative stress induced by monosodium glutamate in rats
The purpose of the present work was to evaluate the possible ameliorative effect ofCoelatura aegyptiaca extract (CE) and vitamin C on oxidative stress induced by monosodium glutamate (MSG) in rat liver. Male rats were randomly divided into four main groups: control group, received distilled water, group 2 (100 mg/kg) and 3 (250 mg/kg) received CE for seven consecutive days. Group animals (24 rats) were administered...
March 2011
Anti glioma effect of doxorubicin loaded liposomes modified with angiopep-2
The low-density lipoprotein receptor-related protein (LRP) was highly expressed in blood brain barrier and glioma cells. Angiopep-2 was a new and effective ligand of LRP. Herein, we present a novel brain targeting delivery system: doxorubicin (DOX) loaded angiopep-2 modified liposome (AL). The particle size of AL was 102 nm and the zeta potential was -9.8 mV, which was stable and suitable for brain targeting delivery....
March 2011
Evaluation of anti-tumor activity of water-soluble polysaccharides from Dendrobium denneanum
Three water-soluble polysaccharides (DDP1-1, DDP2-1 and DDP3-1) were obtained from the aqueous extracts of the stems of Dendrobium denneanum by hot water extraction, ethanol precipitation, and fractionated by DEAE-cellulose ion exchange chromatography and Sephadex G-200 gel filtration chromatography. The main structure characterizations and anti-tumor activities of three fractions were evaluated in this paper....
March 2011
Investigations on DNA protective and antioxidant potential of chloroform and ethyl acetate fractions of Koelreuteria paniculata Laxm.
Reactive oxygen (ROS) species have been known as a contributory factor in the etiology of cancer and various neurodegenerative diseases. ROS are produced as a result of normal metabolic processes occurring in the human body. Therapy using free radical scavengers have the potential to prevent, delay many disorders. The crude extracts and natural pure compounds from plants are reported to have antioxidant activity....
March 2011
Evaluation of biochemical findings in mice exposed to thiamphenicol treatment
The aim of the study was to investigate the acute and subacute dose and the dose regime of thiamphenicol-induced changes in serum biochemical parameters in mice. Thiamphenicol was given to the trial groups at a dosage of 100 mg/kg bw (group 2) and 200 mg/kg bw (group 3) in drinking water for 7 days. Blood samples were collected from all animals on days 1, 3, 7 and 14 of the study. Serum concentrations of urea,...
March 2011
Antihyperglycemic and antioxidant activity of Viscum album extract
The antihyperglycemic and antioxidant effects of water extract of local Viscum album in alloxanized-rats were investigated. This study performed during 2009 in Babol University of medical sciences (Mazandaran Province, Iran). V. album leaves growing on oaks collected and extracted with hot water. The 90 animals that were used in this investigation were male Wistar rats. 60 rats were gavaged with 500...
March 2011
Effects of endurance training on exhaustive exercise-induced oxidative stress markers
This study was aimed to investigate the effects of endurance training on lipid peroxidation and antioxidant enzyme levels in young adults. Twenty four male students participated in this study. Subjects were divided into two groups as training group (n=12) and control group (n=12). Subjects in the training groups performed running exercise 25 to 60 min/day, three days/week for eight weeks at an intensity of 50 to...
March 2011
Efficacy of the combination of herbal extracts and a silicone derivative in the treatment of hypertrophic scar formation after burn injury
The development of hypertrophic scars is an unsolved problem in the process of wound healing. The objective of this research was to study the efficacy of the combination of herbal extracts and a silicone derivative in a gel preparation (Cybele®Scagel) on the treatment of deep second degree burns after complete epithelialization. Sixty-three patients were enrolled in this study. One wound area larger than 10 ×...
March 2011
Synthesis, characterization and biological evaluation of cyclomontanin D
In present study, it was of interest to synthesize a natural proline-rich cyclooligopeptide - cyclomontanin D 8 by coupling of tripeptide Boc-L-Asn(bzh)-L-Pro-Gly-OH and tetrapeptide L-Leu-L-Pro-L-Tyr-L-Ala-OMe followed by cyclization of linear polypeptide fragment. Structure of synthesized cyclopeptide was confirmed by detailed spectral analysis including FTIR, 1H NMR, 13C NMR, ESIMS/MS and elemental...
March 2011
Effects of vitamin B6 on age associated changes of rat brain glutamate decarboxylase activity
Glutamate and gamma-aminobutyric acid (GABA), act as excitatory and inhibitory neurotransmitters in CNS respectively. An increase in glutamate and a decrease in GABA concentration were observed in aged brain. However, the mechanism of these changes has not been very well elucidated. Glutamate decarboxylase (GAD) catalyzes the conversion of glutamate to GABA. Since the vitamin B6 is essential for the activities of GAD,...
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