June 2018

Anti-hyperglycaemic and anti-hyperlipidemic effect of aqueous leaf extract of Vernonia amygdalina in Wistar rats

Diabetes mellitus is a complex metabolic disorder characterised by impaired glucose tolerance and hyperglycemia, which is caused by either lack of or resistance to insulin in tissues; this disease causes significant morbidity and mortality largely due to its end–organ complications. Traditional treatment of diabetes mellitus has involved the use of several plant extracts; in this study the efficacy of aqueous leaf...

Author(s): Ibegbu, Madu D., Nnaemeka, Emmanuel J., Ikele, Ikenna T. and Nwachukwu, Daniel C.  

June 2018

Neurohistological and immunohistochemical effects of prophylactic ethanolic leaf extract of Nauclea latifolia and Artemether/Lumefantrine on the hippocampus of Plasmodium berghei-infected mice

The prophylactic effect of ethanolic leaf extract of Nauclea latifolia, widely used in herbal malarial treatment, was compared against standard drug Coartem® (Artemether/Lumefantrine) in Plasmodium-infected mice was investigated, and thereafter analysed for organosomatic index, parasitemia, histomorphological and immunohistochemical changes in the hippocampus. Twenty male mice about 6 to 8 weeks weighing 20 to 24 g...

Author(s): Innocent A. Edagha, Inyang A. Atting and Moses U. Ekanemesang