July 2014

Evaluation of saliva levels and therapeutic effects of morinidazole, a new 5-nitroimidazole derivative, in patients with periodontal diseases

The aim of this study was to evaluate and compare the saliva and gingival crevice fluid concentrations, as well as therapeutic effects of morinidazole (MNZ) and ornidazole (ONZ) in patients with periodontitis after intravenous (i.v.) infusion administration. 142 outpatient subjects (80 women and 62 men) were enrolled in the phase II clinical trial, and the patients were randomly assigned to receive intravenous infusions...

Author(s): Yong-qing Wang, Ya-ning Mei, Meng Song, Pei-pei Zhang, Ning-ling Jiang, Ling Meng, Ning Ou, Hai-bo Zhang and Lin Yin

July 2014

Design, development and evaluation of diacerein sustained release matrix tablets

This work aims at investigating the use of hydroxy propyl methyl cellulose (HPMC) polymer to formulate sustained release matrix tablets containing diacerein. The sustained release tablets of diacerein were prepared by wet granulation method using HPMC as a release retarding polymer. Various kinetic models were applied to interpret the release of drug from the matrix system. A complete cross over bioavailability study of...

Author(s): Subramania Nainar Meyyanathan, Dhandapani Nagasamy Venkatesh and Karumanchi Harsha Manjusha