African Journal of Pharmacy and Pharmacology
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Article Number - D4E439B33106


Vol.5(8), pp. 1120 - 1124 , August 2011
DOI: 10.5897/AJPP11.421
ISSN: 1996-0816



Full Length Research Paper

The involvement of opioidergic mechanisms in the activity of Bacopa monnieriextract and its toxicological studies


Abbas M1*, Subhan F2, Mohani N1, Rauf K2, Ali G2 and Khan M3




1Department of Pharmacy, Sarhad University of Science and Information Technology, Peshawar, Pakistan.

2Department of Pharmacy, University of Peshawar, Peshawar, Pakistan.

3Department of Pharmacy, University of Malakand, Malakand, Pakistan.


Email: mabbas14@yahoo.com






 Accepted: 29 July 2011  Published: 31 August 2011

Copyright © 2011 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


n-butanol extract (n-Bt ext) of Bacopa monnieri (BM) was studied for antinociceptive effect in the animal models of acetic acid induced writhing and hot plate tests. The extract exhibited significant antinociceptive activity (P<0.01) in these tests. Standard centrally acting analgesic, morphine, peripherally acting and diclofenac were also tested along with the extract for comparison. The antinociceptive effect of the extract was antagonized by the opioid receptor antagonist, naloxone in a fashion similar to morphine that indicated the involvement of opioids in the mediation of antinociceptive response of BM. Toxicolgical studies indicated that n-Bt ext is comparatively toxic. These results indicate that BM possesses antinociceptive activity that may be mediated through interaction with opioid receptors.

 

Key words: Bacopa monnieri, n-butanol extract, antinociceptive activity, acetic acid induced writhing test, hot plate test, toxicological studies.


APA (2011). The involvement of opioidergic mechanisms in the activity of Bacopa monnieriextract and its toxicological studies. African Journal of Pharmacy and Pharmacology, 5(8), 1120 - 1124.
Chicago Abbas M, Subhan F, Mohani N, Rauf K, Ali G and Khan M. "The involvement of opioidergic mechanisms in the activity of Bacopa monnieriextract and its toxicological studies." African Journal of Pharmacy and Pharmacology 5, no. 8 (2011): 1120 - 1124.
MLA Abbas M, et al. "The involvement of opioidergic mechanisms in the activity of Bacopa monnieriextract and its toxicological studies." African Journal of Pharmacy and Pharmacology 5.8 (2011): 1120 - 1124.
   
DOI 10.5897/AJPP11.421
URL http://www.academicjournals.org/journal/AJPP/article-abstract/D4E439B33106

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