n-butanol extract (n-Bt ext) of Bacopa monnieri (BM) was studied for antinociceptive effect in the animal models of acetic acid induced writhing and hot plate tests. The extract exhibited significant antinociceptive activity (P<0.01) in these tests. Standard centrally acting analgesic, morphine, peripherally acting and diclofenac were also tested along with the extract for comparison. The antinociceptive effect of the extract was antagonized by the opioid receptor antagonist, naloxone in a fashion similar to morphine that indicated the involvement of opioids in the mediation of antinociceptive response of BM. Toxicolgical studies indicated that n-Bt ext is comparatively toxic. These results indicate that BM possesses antinociceptive activity that may be mediated through interaction with opioid receptors.
Key words: Bacopa monnieri, n-butanol extract, antinociceptive activity, acetic acid induced writhing test, hot plate test, toxicological studies.
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