African Journal of Pharmacy and Pharmacology
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Article Number - 95D889336841


Vol.6(4), pp. 248 - 252 , January 2012
DOI: 10.5897/AJPP11.701
ISSN: 1996-0816



Full Length Research Paper

Effects of rosmarinic acid on male sex hormones (testosterone-FSH-LH) and testis tissue apoptosis after exposure to electromagnetic field (EMF) in rats


Arash Khaki1*, S. A. M. Imani2 and Farhad S. Golzar1




1Department of Veterinary Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran.

2Young Researchers Club, Tabriz Branch, Islamic Azad University, Tabriz, Iran.


Email: arashkhaki@yahoo.com






 Published: 29 January 2012

Copyright © 2012 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Rosmarinic acid (RA) is a polyphenol derived from many common herbal plants of the Lamiaceae group: Rosemary, sage, Spanish sage, oregano, basil, marjoram, thyme, the mint group, lavender, perilla and lemon balm. It is currently being studied for its effects on Alzheimer's disease and some other diseases. Rosmarinic acid in its natural state as part of a herb has been used to strengthen the memory and to improve mood by dispersing melancholy. Male Wistar rats (n = 40) were allocated to four groups, a control group (n = 10) and three treatment groups (n = 30). The first treatment group received rosmarinic acid (5 mg/kg body weight), the second extract group received rosmarinic acid (5 mg/kg body weight) and electromagnetic field (EMF) exposure at 50 Hz for 40 consecutive days, whilst the forth group received only EMF exposure for 40 consecutive days. Animals were maintained under standard conditions. At the conclusion of the test period, rat testes tissues were removed from all group members and animals were maintained under standard conditions. Tissue preparation was performed and analyzed for apoptosis. There was a significant increase in apoptosis in EMF group and significant increase in testosterone serum level in RA group when compared with other groups (P < 0.05). EMF has negative effect on testis histology in rats. However, these side effects are less seen in the EMF group that received RA. Therefore, it is recommended that usage of rosmarinic acid in modern country has fewer industrial side effects on male fertility.

 

Key words: Apoptosis, electromagnetic field (EMF), male fertility, rosmarinic acid, testis.


APA (2012). Effects of rosmarinic acid on male sex hormones (testosterone-FSH-LH) and testis tissue apoptosis after exposure to electromagnetic field (EMF) in rats. African Journal of Pharmacy and Pharmacology, 6(4), 248 - 252.
Chicago Arash Khaki, S. A. M. Imani and Farhad S. Golzar. "Effects of rosmarinic acid on male sex hormones (testosterone-FSH-LH) and testis tissue apoptosis after exposure to electromagnetic field (EMF) in rats." African Journal of Pharmacy and Pharmacology 6, no. 4 (2012): 248 - 252.
MLA Arash Khaki, S. A. M. Imani and Farhad S. Golzar. "Effects of rosmarinic acid on male sex hormones (testosterone-FSH-LH) and testis tissue apoptosis after exposure to electromagnetic field (EMF) in rats." African Journal of Pharmacy and Pharmacology 6.4 (2012): 248 - 252.
   
DOI 10.5897/AJPP11.701
URL http://www.academicjournals.org/journal/AJPP/article-abstract/95D889336841

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