African Journal of Microbiology Research
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Article Number - ED88B0D66172


Vol.11(35), pp. 1360-1370 , September 2017
DOI: 10.5897/AJMR2016.8181
ISSN: 1996-0808



Review

Value of matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry in clinical microbiology and infectious diseases in Africa and tropical areas



Christophe Flaudrops
  • Christophe Flaudrops
  • Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France.
  • Google Scholar
Ngor Faye
  • Ngor Faye
  • Laboratory of General Parasitology, Cheikh Anta Diop University, Dakar, Senegal.
  • Google Scholar
Oleg Mediannikov
  • Oleg Mediannikov
  • Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France.
  • Google Scholar
Cheikh Sokhna
  • Cheikh Sokhna
  • Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France.
  • Google Scholar
Cheikh Ibrahima Lo
  • Cheikh Ibrahima Lo
  • Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France.
  • Google Scholar
Bécaye Fall
  • Bécaye Fall
  • Hôpital Principal de Dakar, Senegal.
  • Google Scholar
Bissoume Sambe-Ba
  • Bissoume Sambe-Ba
  • Hôpital Principal de Dakar, Senegal.
  • Google Scholar
Boubacar Wade
  • Boubacar Wade
  • Hôpital Principal de Dakar, Senegal.
  • Google Scholar
Didier Raoult
  • Didier Raoult
  • Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France.
  • Google Scholar
Florence Fenollar
  • Florence Fenollar
  • Aix-Marseille Université, Unité de Recherche sur les Maladies Infectieuses Tropicales et Emergentes, UM63, CNRS 7278, IRD 198, INSERM 1095, Marseille, France.
  • Google Scholar







 Received: 24 June 2017  Accepted: 11 September 2017  Published: 21 September 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


Matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry (MALDI-TOF MS) is a revolutionary technique with multiple applications. Its use in clinical microbiology is now becoming widespread as the method is an easy, rapid, effective, accurate, and cheap way to identify cultured bacteria and fungi. It is, therefore, an ideal tool to replace conventional methods still used in Africa and tropical areas for routine microbiological diagnosis. The recent installation of a MALDI-TOF MS for diagnostic purposes in a hospital in Senegal has confirmed that this tool is not only valuable but also robust in tropical Africa, providing further evidence that this technique should be widely distributed there. However, despite its value for clinical microbiology in Africa, the acquisition and installation of MALDI-TOF MS is subject to several constraints. This review provides general information on aspects of MALDI-TOF MS. The specific aspects and constraints observed in Africa and tropical countries are also addressed with suggestions for appropriate solutions.

Key words: Microorganism, infectious diseases, quick identification, matrix-assisted laser desorption-ionization time-of-flight, matrix assisted laser desorption ionization-time of flight (MALDI-TOF).

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APA Lo, C. I., Fall, B., Sambe-Ba, B., Flaudrops, C., Faye, N., Mediannikov, O., Sokhna, C., Wade, B., Raoult, D., & Fenollar, F. (2017). Value of matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry in clinical microbiology and infectious diseases in Africa and tropical areas. African Journal of Microbiology Research, 11(35), 1360-1370.
Chicago Cheikh Ibrahima Lo, B&ecaye Fall, Bissoume Sambe-Ba, Christophe Flaudrops, Ngor Faye, Oleg Mediannikov, Cheikh Sokhna, Boubacar Wade, Didier Raoult and Florence Fenollar. "Value of matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry in clinical microbiology and infectious diseases in Africa and tropical areas." African Journal of Microbiology Research 11, no. 35 (2017): 1360-1370.
MLA Cheikh Ibrahima Lo, et al. "Value of matrix assisted laser desorption ionization-time of flight (MALDI-TOF) mass spectrometry in clinical microbiology and infectious diseases in Africa and tropical areas." African Journal of Microbiology Research 11.35 (2017): 1360-1370.
   
DOI 10.5897/AJMR2016.8181
URL http://www.academicjournals.org/journal/AJMR/article-abstract/ED88B0D66172

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