African Journal of Microbiology Research
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Article Number - C523BC620906


Vol.6(3), pp. 653-659 , January 2012
DOI: 10.5897/AJMR11.395
ISSN: 1996-0808



Full Length Research Paper

The effects of LD50 of Walterinnesia aegyptia crude venom on blood parameters of male rats


Mohamed K. Al-Sadoon1*, Assem Fahim1, Safwat F. Salama1,2 and Gamal Badr1,3

 



1Department of Zoology, College of Science, King Saud University, Saudi Arabia.

2Department Radiation Biology, National Centre for Radiation Research and Technology, Egypt.

3Zoology Department, Faculty of Science, Assiut University, Egypt


Email: msadoon@ksu.edu.sa






 Accepted: 14 December 2011  Published: 23 January 2012

Copyright © 2012 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


The effects of an acute LD50 dose of Walterennesia aegyptia crude venom was studied in male albino rats over a period of seven days. The following analyses were performed at timed intervals of 1 h, 3 h, 6 h, 12 h, 24 h, 72 h and 7 days: white blood cells (WBC), red blood cells (RBC), Platelets count, hemoglobin content (Hb), hematocrit (Hct) and blood indices [Mean Cell Volume (MCV), mean cell hemoglobin (MCH) and mean cell hemoglobin concentration (MCHC)]. Serum enzymatic activities include alanine transaminase (ALT), aspartate transaminase (AST), γ-glutamyl transferase (γ-GT) andalkaline phosphatase (ALP), with the following metabolites concentrations (glucose, total protein, triglycerides and creatinine). These parameters were found to fluctuate with time, with tendency to regain normal control level within the first 6 h. The 12 to 24 h seems to be crucial for the process of physiological recovery. The process of physiological adaptation and recovery from LD50 venom dose seems to stabilize after one week, leaving the animal alive with several lesions and disturbed physiological profile.

Key words: Blood parameters, crude venom, enzymes, LD50, metabolites, Walterinnesia aegyptia


APA (2012). The effects of LD50 of Walterinnesia aegyptia crude venom on blood parameters of male rats. African Journal of Microbiology Research, 6(3), 653-659.
Chicago Mohamed K. Al-Sadoon, Assem Fahim, Safwat F. Salama, and Gamal Badr,  . "The effects of LD50 of Walterinnesia aegyptia crude venom on blood parameters of male rats." African Journal of Microbiology Research 6, no. 3 (2012): 653-659.
MLA Mohamed K. Al-Sadoon, et al. "The effects of LD50 of Walterinnesia aegyptia crude venom on blood parameters of male rats." African Journal of Microbiology Research 6.3 (2012): 653-659.
   
DOI 10.5897/AJMR11.395
URL http://www.academicjournals.org/journal/AJMR/article-abstract/C523BC620906

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