African Journal of Microbiology Research
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Article Number - 83043E267087


Vol.11(46), pp. 1657-1662 , December 2017
DOI: 10.5897/AJMR2017.8719
ISSN: 1996-0808



Full Length Research Paper

A retrospective study of antibiotic sensitivity pattern of uropathogens in the Federal Capital Territory, Nigeria



Michael P. Okoh
  • Michael P. Okoh
  • Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, University of Abuja, FCT, Nigeria.
  • Google Scholar
Halima M. Habi
  • Halima M. Habi
  • Department of Microbiology, Faculty of Science, University of Abuja, FCT, Nigeria.
  • Google Scholar
Salamatu S. Machunga-Mambula
  • Salamatu S. Machunga-Mambula
  • Department of Microbiology, Faculty of Science, University of Abuja, FCT, Nigeria.
  • Google Scholar







 Received: 25 September 2017  Accepted: 30 November 2017  Published: 14 December 2017

Copyright © 2017 Author(s) retain the copyright of this article.
This article is published under the terms of the Creative Commons Attribution License 4.0


This study was designed to bring to the fore the prevalent causative agents of urinary tract infections (UTIs) and their antibiotic susceptibility patterns in Nigeria, using patients attending University of Abuja Teaching Hospital (UATH) as a case study. Using microbiological/biochemical methods, prevalence of uropathogens amongst sexes, was compared between 2010 and 2015. Bacterial counts (105/ml) in the urine was used as quantitative standard and the total number of patients in the study was 214 (166 females and 48 males). The prevalence of UTIs in samples collected from 214 patients between 2010 and 2015 shows that Escherichia coli (57.5%) was the most prevalent organism causing UTIs, followed by Klebsiella species (18.5%), Staphylococcus aureus (11.2%) and Proteus species (12.4%). Antibiotics used include nitrofurantoin, ofloxacin, nalidixic acid, amoxicillin, gentamicin, tetracycline, levofloxacin, and augumentin, with bacterial causing UTI displaying greatest resistance to tetracycline and nitrofurantoin the highest sensitivity. This study indicates most of the uropathogens are still susceptible to antibiotics commonly used in the hospital. However, E. coli exhibited resistance to amoxicillin. The development of antimicrobials for prevention and treatment of infections should be tackled from a worldwide understanding of infection patterns so as to overcome the increasing level of superbugs in general and UTIs in particular.
 
Key words: Urinary tract infections, microbial resistance, adaptive immune response.

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APA Okoh, M. P., Habi, H. M., & Machunga-Mambula, S. S. (2017). A retrospective study of antibiotic sensitivity pattern of uropathogens in the Federal Capital Territory, Nigeria. African Journal of Microbiology Research, 11(46), 1657-1662.
Chicago Michael P. Okoh, Halima M. Habi and Salamatu S. Machunga-Mambula. "A retrospective study of antibiotic sensitivity pattern of uropathogens in the Federal Capital Territory, Nigeria." African Journal of Microbiology Research 11, no. 46 (2017): 1657-1662.
MLA Michael P. Okoh, Halima M. Habi and Salamatu S. Machunga-Mambula. "A retrospective study of antibiotic sensitivity pattern of uropathogens in the Federal Capital Territory, Nigeria." African Journal of Microbiology Research 11.46 (2017): 1657-1662.
   
DOI 10.5897/AJMR2017.8719
URL http://www.academicjournals.org/journal/AJMR/article-abstract/83043E267087

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